SPTLC2

Entrez Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011].
UniProt Summary: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:20920666}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lapatinib 5μM R01 exp47	-4.08
Q15 1 to 2μM on day4 R04 exp164	-3.75
DABN 20μM R00 exp17	-3.71
Momordin-Ic 10μM R08 exp506	-3.69
Pterostilbene 16μM R02 exp78	-3.59
Q15 2.7μM R02 exp79	-3.52
Clomiphene 4.4μM R02 exp68	-3.31
UM0125461 0.74μM R02 exp84	-3.22
ZLN024 50μM R08 exp538	-3.18
WYE-354 6μM R02 exp90	-3.04
BH1 1μM R04 exp169	-2.85
Monensin 0.3μM R08 exp507	-2.82
IWR1 50μM R08 exp495	-2.64
SB203580 25μM R03 exp149	-2.38
BVD-523 15μM R02 exp67	-2.3
Bortezomib 0.05μM R00 exp7	-2.29
Docosahexaenoic-acid 50μM R07 exp356	-2.15
Brefeldin A 0.02μM R00 exp8	-2.11
BS-181 20μM R08 exp461	-2.06
Nicotine 3000μM R08 exp510	-2.01
Oligomycin-A 20μM R00 exp26	-1.99
Vemurafenib 6.6μM R02 exp89	-1.94
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.94
MLN-4924 2μM R00 exp22	-1.93
Tubacin 1.6μM R07 exp416	-1.92
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.89
Wortmannin 0.5μM R00 exp37	-1.88
SGC0946 7μM R03 exp151	-1.81
CFI-400945 25μM R08 exp469	-1.76
Vitamin-D3 40μM R08 exp536	-1.74
TRAIL 5ng/ml R00 exp35	1.72
Olaparib 4μM R08 exp512	1.82
Arsenate 40μM R06 exp264	1.94
Amiloride 100μM R08 exp447	2.12

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sphinganine biosynthetic process
sphinganine metabolic process
serine C-palmitoyltransferase complex
positive regulation of lipophagy
serine C-palmitoyltransferase activity
regulation of lipophagy
sphingomyelin biosynthetic process
sphingosine biosynthetic process
sphingoid biosynthetic process
sphingosine metabolic process
sphingomyelin metabolic process
sphingoid metabolic process
diol biosynthetic process
diol metabolic process
adipose tissue development
ceramide biosynthetic process
pyridoxal phosphate binding
polyol biosynthetic process
positive regulation of macroautophagy
ceramide metabolic process
sphingolipid biosynthetic process
polyol metabolic process
alcohol biosynthetic process
positive regulation of autophagy
membrane lipid biosynthetic process
sphingolipid metabolic process
regulation of macroautophagy
organic hydroxy compound biosynthetic process
ammonium ion metabolic process
membrane lipid metabolic process
connective tissue development
phospholipid biosynthetic process
alcohol metabolic process
regulation of autophagy
positive regulation of cellular catabolic process
phospholipid metabolic process
positive regulation of catabolic process
organic hydroxy compound metabolic process
amide biosynthetic process
organophosphate biosynthetic process