SUGT1

Entrez Summary: This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016].
UniProt Summary: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lapatinib 5μM R01 exp47	-3.95
2-Methoxyestradiol 0.55μM R07 exp310	-2.87
PT-1 25μM R07 exp392	-2.86
HMS-I1 1μM R01 exp46	-2.57
Taxol 0.002μM R01 exp54	-2.37
Docetaxel 0.002μM R01 exp45	-2.19
Radicicol 0.16μM R05 exp242	-2.14
Genistein 15μM R07 exp360	-2.13
3-Bromopyruvate 7μM R04 exp175	-2.11
Fluvastatin 2.2μM R06 exp282	-2.11
Bortezomib 0.005μM R00 exp6	-2.08
LLY-283 2.6μM R06 exp290	-1.99
Nicotinamide 2000μM R01 exp50	-1.98
All-trans-Retinoic-Acid 8μM R07 exp333	-1.93
Sulforaphane 9μM R08 exp525	-1.93
Ethanol 0.01 R05 exp234	-1.91
GSK626616 14μM R08 exp485	-1.9
Asunaprenir 3μM R07 exp336	-1.87
BVD-523 15μM R02 exp67	-1.83
BI-2536 0.0042μM R03 exp95	-1.82
Colchicine 0.009μM R05 exp215	-1.82
Tubacin 1.6μM R07 exp416	-1.82
YM155 0.0002μM R01 exp61	-1.81
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.71
BI-2536 0.02μM R03 exp96	1.74
Vemurafenib 6.6μM R08 exp434	1.97
Hippuristanol 0.12μM R08 exp488	2.04
CyclicAMP 200μM R08 exp475	2.23
SB202190 10μM R03 exp148	2.29

Global Fraction of Cell Lines Where Essential: 94/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	3/28
bone	6/26
breast	2/33
central nervous system	11/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	1/1
gastric	0/16
kidney	2/21
liver	4/20
lung	14/75
lymphocyte	1/16
ovary	3/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	3/15
prostate	0/1
skin	6/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	2/5

Expression Distribution

SGS
CS

positive regulation of catalytic activity in other organism involved in symbiotic interaction
positive regulation by host of symbiont catalytic activity
modulation by host of symbiont catalytic activity
modulation of catalytic activity in other organism involved in symbiotic interaction
negative regulation by host of symbiont molecular function
modulation by host of symbiont molecular function
negative regulation of molecular function in other organism
negative regulation of molecular function in other organism involved in symbiotic interaction
modulation of molecular function in other organism involved in symbiotic interaction
modulation of molecular function in other organism
modification by host of symbiont morphology or physiology
interaction with symbiont
kinetochore
ubiquitin ligase complex
modification of morphology or physiology of other organism involved in symbiotic interaction
modification of morphology or physiology of other organism
protein stabilization
regulation of protein stability
protein-containing complex
mitotic cell cycle
symbiotic process
interspecies interaction between organisms
negative regulation of molecular function
cell cycle