XPR1

Entrez Summary: The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016].
UniProt Summary: Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5- InsP7); these are important intracellular signaling molecules (PubMed:27080106). {ECO:0000250|UniProtKB:Q9Z0U0, ECO:0000269|PubMed:23791524, ECO:0000269|PubMed:25938945, ECO:0000269|PubMed:27080106}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thimerosal 0.85μM R08 exp529	-3.18
Hippuristanol 0.12μM R08 exp488	-2.95
Cryptotanshinone 12μM R05 exp227	-2.51
Citral 75μM R06 exp275	-2.47
Dynasore 7μM R08 exp436	-2.4
Etoposide 1μM R00 exp19	-2.4
Hydroxyurea 100μM R07 exp329	-2.32
Vincristine 0.0005μM R04 exp190	-2.31
Diepoxybutane 3μM R07 exp354	-2.28
MS023 2μM R03 exp134	-2.23
Trimetrexate 0.03μM R08 exp535	-2.23
Citral 50μM R06 exp274	-2.19
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.11
Etoposide 0.3μM R05 exp199	-2.05
Latrunculin-B 10μM R07 exp374	-2.01
Mubritinib 0.2μM R01 exp48	-2
Colchicine 0.009μM R05 exp215	-1.99
ETC-159 50μM R08 exp480	-1.99
FTY720 3μM R08 exp483	-1.96
Epigallocatechin gallate 20μM R05 exp230	-1.94
Rucaparib 6.5μM R08 exp520	-1.94
Apcin 50 to 100μM on day4 R04 exp176	-1.9
Pterostilbene 16μM R02 exp78	-1.88
LY2090314 0.003μM R08 exp500 no dilution day6	-1.84
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.82
CB-5083 0.4μM R08 exp468	-1.81
EPZ-5676 30μM R05 exp233	-1.8
Sulforaphane 9μM R08 exp526 no dilution day6	-1.8
Menadione 5μM R06 exp292	-1.79
Nutlin-3A 1.6μM R06 exp294	-1.78
Artemisinin 50μM R08 exp450	-1.76
3-Bromopyruvate 7μM R04 exp175	-1.73
KU-0063794 3.8μM R02 exp71	1.94
Dinaciclib 0.007μM R07 exp355	2.27
Oligomycin-A 2μM R00 exp25	2.27
GSK461364A 0.005μM R03 exp125	2.68
Milciclib 2μM R08 exp502	3.11
BI-6727 0.0125μM R03 exp97	3.85
BI-2536 0.0042μM R03 exp95	4.3
Arsenate 40μM R06 exp264	8.46

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	3/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

EXS
SPX

cellular response to phosphate starvation
phosphate ion transmembrane transporter activity
inositol hexakisphosphate binding
efflux transmembrane transporter activity
cellular divalent inorganic anion homeostasis
cellular trivalent inorganic anion homeostasis
cellular phosphate ion homeostasis
phosphate ion homeostasis
divalent inorganic anion homeostasis
trivalent inorganic anion homeostasis
cellular monovalent inorganic anion homeostasis
cellular anion homeostasis
phosphate ion transmembrane transport
phosphate ion transport
monovalent inorganic anion homeostasis
intrinsic component of plasma membrane
anion homeostasis
virus receptor activity
viral entry into host cell
entry into host cell
entry into host
inorganic anion transmembrane transport
transmembrane signaling receptor activity
cellular response to starvation
interaction with host
inorganic anion transport
response to starvation
viral life cycle
signaling receptor activity
cellular response to nutrient levels
cellular response to extracellular stimulus
anion transmembrane transport
response to virus
cellular response to external stimulus
response to nutrient levels
response to extracellular stimulus
anion transport
cellular ion homeostasis
inorganic ion transmembrane transport
viral process