DLGAP5
Gene Information
- Official Symbol: DLGAP5
- Official Name: DLG associated protein 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 9787
- UniProt: Q15398
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}.
Pfam Domains GO Terms
Pfam Domains
| GKAP |
GO Terms
| mitotic chromosome movement towards spindle pole |
| chromosome movement towards spindle pole |
| positive regulation of mitotic sister chromatid separation |
| positive regulation of mitotic metaphase/anaphase transition |
| positive regulation of metaphase/anaphase transition of cell cycle |
| positive regulation of chromosome separation |
| spindle pole centrosome |
| positive regulation of mitotic sister chromatid segregation |
| positive regulation of transcription of Notch receptor target |
| positive regulation of chromosome segregation |
| phosphoprotein phosphatase activity |
| regulation of mitotic metaphase/anaphase transition |
| positive regulation of mitotic nuclear division |
| regulation of metaphase/anaphase transition of cell cycle |
| regulation of mitotic sister chromatid separation |
| regulation of chromosome separation |
| positive regulation of nuclear division |
| regulation of mitotic sister chromatid segregation |
| establishment of chromosome localization |
| chromosome localization |
| positive regulation of mitotic cell cycle phase transition |
| regulation of sister chromatid segregation |
| positive regulation of cell cycle phase transition |
| regulation of chromosome segregation |
| mitotic sister chromatid segregation |
| Notch signaling pathway |
| sister chromatid segregation |
| mitotic nuclear division |
| positive regulation of mitotic cell cycle |
| microtubule organizing center |
| regulation of mitotic nuclear division |
| positive regulation of chromosome organization |
| regulation of nuclear division |
| protein dephosphorylation |
| nuclear chromosome segregation |
| microtubule-based movement |
| chromosome segregation |
| nuclear division |
| positive regulation of cell cycle process |
| dephosphorylation |
| organelle fission |
| regulation of chromosome organization |
| establishment of organelle localization |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| cell population proliferation |
| organelle localization |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| microtubule-based process |
| mitotic cell cycle |
| regulation of cell cycle process |
| cell cycle process |
| chromosome organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| mitochondrion |
| regulation of organelle organization |
| cell cycle |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| establishment of localization in cell |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6935
- Expression level (log2 read counts): 6.87
Expression Distribution
DLGAP5 Expression in NALM6 Cells: 6.87
