SEC61G

Gene Information

Official Symbol: SEC61G
Official Name: SEC61 translocon subunit gamma
Aliases and Previous Symbols: N/A
Entrez ID: 23480
UniProt: P60059
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Necessary for protein translocation in the endoplasmic reticulum. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubastatin-A 2.5μM R07 exp417	-1.88
Pomalidomide 20μM R07 exp391	-1.82
Thapsigargin 0.005μM R07 exp407	-1.8
Talazoparib 0.006μM R06 exp299	-1.79
Hinokiflavone 12μM R08 exp487	1.75
Etoposide 0.3μM R05 exp199	1.85
GSK461364A 0.1μM R03 exp126	1.91
THZ1 0.06μM R08 exp531	2.25

Gene	Correlation
HSPD1	0.539
RNMT	0.525
TRIAP1	0.523
GMPPB	0.512
THG1L	0.502
PMM2	0.5
NAE1	0.498
GTF3C6	0.492
APAF1	0.481
ADSL	0.474
GTF3C2	0.459
UAP1	0.458
BAP1	0.456
PIK3R4	0.454
TRNT1	0.45
HCCS	0.449
RPTOR	0.445
CYCS	0.443
ATP2A2	0.443
EIF4E	0.439
ROMO1	0.438
CSNK2B	0.437
VRK1	0.437
GFPT1	0.435
DAD1	0.434
SPCS2	0.433
ATXN10	0.433
MEAF6	0.432
DPAGT1	0.431
UTP23	0.428
AARS	0.427
ENY2	0.426
DOHH	0.425
RPP21	0.423
DPF2	0.422
SRP14	0.422
ALG13	0.416
BAK1	0.416
ALG1	0.416
CTDNEP1	0.416
PLAA	0.415
GTF3C3	0.415
RTCB	0.415
ALG5	0.414
RPE	0.413
GTF3C4	0.413
CASP9	0.412
CHCHD4	0.411
ZNHIT1	0.41
SSB	0.41
HAUS8	0.407
VEZT	0.406
MTOR	0.405
TELO2	0.403
PISD	0.403
RPN1	0.403
CBFB	0.401
TSEN54	0.401
EIF1AX	0.401
PPCS	0.401
TRMT5	0.4

Global Fraction of Cell Lines Where Essential: 254/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	11/28
blood	10/28
bone	8/26
breast	15/33
central nervous system	17/56
cervix	2/4
colorectal	3/17
esophagus	4/13
fibroblast	1/1
gastric	3/16
kidney	11/21
liver	11/20
lung	27/75
lymphocyte	5/16
ovary	10/26
pancreas	1/24
peripheral nervous system	8/16
plasma cell	8/15
prostate	0/1
skin	2/24
soft tissue	6/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	11/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 3961
Expression level (log2 read counts): 5.27

Expression Distribution