SMG5
Gene Information
- Official Symbol: SMG5
- Official Name: SMG5 nonsense mediated mRNA decay factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 23381
- UniProt: Q9UPR3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}.
Pfam Domains GO Terms
Pfam Domains
| EST1 |
GO Terms
| telomerase holoenzyme complex |
| telomere maintenance via telomerase |
| telomerase RNA binding |
| telomeric DNA binding |
| telomere maintenance via telomere lengthening |
| protein phosphatase 2A binding |
| RNA-dependent DNA biosynthetic process |
| regulation of telomere maintenance via telomerase |
| regulation of telomere maintenance via telomere lengthening |
| regulation of telomere maintenance |
| telomere maintenance |
| telomere organization |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| mRNA export from nucleus |
| DNA biosynthetic process |
| histone deacetylase binding |
| regulation of DNA biosynthetic process |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| protein export from nucleus |
| mRNA transport |
| nuclear export |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| nuclear-transcribed mRNA catabolic process |
| regulation of dephosphorylation |
| RNA localization |
| mRNA catabolic process |
| nucleobase-containing compound transport |
| RNA catabolic process |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| ubiquitin protein ligase binding |
| anatomical structure homeostasis |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| nucleobase-containing compound catabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| organic cyclic compound catabolic process |
| mRNA metabolic process |
| DNA metabolic process |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 407/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 9/28 |
| blood | 19/28 |
| bone | 16/26 |
| breast | 20/33 |
| central nervous system | 29/56 |
| cervix | 2/4 |
| colorectal | 15/17 |
| esophagus | 4/13 |
| fibroblast | 0/1 |
| gastric | 8/16 |
| kidney | 9/21 |
| liver | 11/20 |
| lung | 43/75 |
| lymphocyte | 11/16 |
| ovary | 17/26 |
| pancreas | 13/24 |
| peripheral nervous system | 8/16 |
| plasma cell | 10/15 |
| prostate | 0/1 |
| skin | 13/24 |
| soft tissue | 7/9 |
| thyroid | 0/2 |
| upper aerodigestive | 11/22 |
| urinary tract | 13/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 280
- Expression level (log2 read counts): 7.48
Expression Distribution
SMG5 Expression in NALM6 Cells: 7.48
