Table of Contents

Dynasore 10μM R04 exp180

Mechanism of Action

Putative dynamin GTPase inhibitor, blocks endocytosis

Technical Notes

Compound References

  • PubChem Name: Dynasore
  • Synonyms: N/A
  • CAS #: 304448-55-3
  • PubChem CID: 135533054
  • IUPAC: N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide
  • INCHI Name: InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
  • INCHI Key: SYNDQCRDGGCQRZ-VXLYETTFSA-N
  • Molecular Weight: 322.3
  • Canonical SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O
  • Isomeric SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
  • Molecular Formula: C18H14N2O4

Compound Supplier

  • Supplier Name: ChemCruz
  • Catalog #: SC-202592
  • Lot #: B2216

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C18H14N2O4 323.10263; found 323.10352

Dose Response Curve

  • Platform ID: Dynasore
  • Min: -1.6097; Max: 96.5116





IC Concentration (µM)
IC10 N/A
IC20 8.6593
IC30 10.6253
IC40 12.5655
IC50 14.6562
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
23/8ScoresViewViewViewViewView