Cerivastatin 0.15μM R05 exp226

Inhibits HMG-CoA reductase, decreases cholesterol biogenesis, upregulates LDL receptors

PubChem Name: Cerivastatin sodium
Synonyms: N/A
CAS #: 143201-11-0
PubChem CID: 23663992
IUPAC: sodium;(E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate
INCHI Name: InChI=1S/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1
INCHI Key: GPUADMRJQVPIAS-QCVDVZFFSA-M
Molecular Weight: 481.5
Canonical SMILES: CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)C=CC(CC(CC(=O)[O-])O)O.[Na+]
Isomeric SMILES: CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)/C=C/[C@H](C[C@H](CC(=O)[O-])O)O.[Na+]
Molecular Formula: C26H33FNNaO5

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
57/46	Scores	View	View	View	View	View

GO Term	Fold Change	Genes
positive regulation of sterol biosynthetic process	263.02	SREBF2,SCAP,ABCG1
positive regulation of cholesterol metabolic process	153.43	SREBF2,SCAP,ABCG1
regulation of sterol biosynthetic process	136.38	SCAP,MBTPS2,MBTPS1,ABCG1
regulation of cholesterol biosynthetic process	136.38	SREBF2,MBTPS2,MBTPS1,ABCG1
COPII-coated vesicle cargo loading	131.51	SCAP,RAB1A,SEC31A
positive regulation of steroid biosynthetic process	92.06	SREBF2,SCAP,ABCG1
regulation of cholesterol metabolic process	90.25	SREBF2,SCAP,MBTPS2,MBTPS1,ABCG1
ER-nucleus signaling pathway	87.67	SREBF2,SCAP,MBTPS2,MBTPS1
positive regulation of alcohol biosynthetic process	76.71	SREBF2,SCAP,ABCG1
regulation of alcohol biosynthetic process	63.93	SREBF2,SCAP,MBTPS2,MBTPS1,ABCG1
regulation of steroid biosynthetic process	42.03	SREBF2,SCAP,MBTPS2,MBTPS1,ABCG1
ER to Golgi transport vesicle membrane	41.61	SREBF2,SCAP,USO1,SEC31A
regulation of steroid metabolic process	32.30	SREBF2,SCAP,MBTPS2,MBTPS1,ABCG1
cholesterol metabolic process	26.68	SREBF2,SCAP,MBTPS2,MBTPS1,ABCG1
endoplasmic reticulum to Golgi vesicle-mediated transport	24.75	SCAP,RAB1B,RAB1A,USO1,SEC31A
secondary alcohol metabolic process	24.55	SREBF2,SCAP,MBTPS2,MBTPS1,ABCG1
sterol metabolic process	23.97	SREBF2,SCAP,MBTPS2,MBTPS1,ABCG1
Golgi vesicle transport	17.92	SCAP,RAB1B,COG7,SLC10A7,RAB1A,USO1,SEC31A,PITPNB
Golgi membrane	13.12	SREBF2,SCAP,RAB1B,RIC1,UNC50,MBTPS2,COG7,SLC10A7,RAB1A,USO1,MBTPS1,ENTPD4,PITPNB,ABCG1

GO Term	Fold Change	Genes
protein import into peroxisome matrix, receptor recycling	276.17	PEX6,PEX12,PEX1
protein import into peroxisome matrix	157.81	PEX6,PEX12,PEX1,PEX26
peroxisomal membrane transport	157.81	ABCD3,PEX6,PEX3,PEX12,PEX1,PEX26
protein targeting to peroxisome	145.35	PEX6,PEX3,PEX12,PEX1,PEX26
peroxisomal transport	144.09	ABCD3,PEX6,PEX3,PEX12,PEX1,PEX26
protein localization to peroxisome	116.28	PEX6,PEX3,PEX12,PEX26
establishment of protein localization to peroxisome	116.28	PEX6,PEX12,PEX1,PEX26
peroxisome organization	100.42	ABCD3,PEX6,PEX3,PEX12,PEX1,PEX26
microbody membrane	60.41	ABCD3,ACSL3,PEX6,PEX3,PEX12,PEX1,PEX26
peroxisomal membrane	60.41	ABCD3,ACSL3,PEX6,PEX3,PEX12,PEX1,PEX26
protein transmembrane import into intracellular organelle	59.71	PEX6,PEX12,PEX1,PEX26
intracellular protein transmembrane transport	41.69	PEX6,PEX12,PEX1,PEX26
microbody	27.04	ABCD3,ACSL3,PEX6,PEX3,PEX12,PEX1,PEX26
peroxisome	27.04	ABCD3,ACSL3,PEX6,PEX3,PEX12,PEX1,PEX26
steroid biosynthetic process	24.88	ABCD3,FDFT1,SREBF1,INSIG1,HSD17B12
cholesterol metabolic process	24.01	LDLRAP1,LDLR,FDFT1,SREBF1,INSIG1
secondary alcohol metabolic process	22.09	LDLRAP1,LDLR,FDFT1,SREBF1,INSIG1
sterol metabolic process	21.58	LDLRAP1,LDLR,FDFT1,SREBF1,INSIG1
steroid metabolic process	15.34	LDLRAP1,LDLR,ABCD3,FDFT1,SREBF1,INSIG1,HSD17B12