Table of Contents

Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471

Mechanism of Action

Major membrane lipid, precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D

Technical Notes

Compound References

  • PubChem Name: Cholesterol
  • Synonyms: N/A
  • CAS #: 57-88-5
  • PubChem CID: 5997
  • IUPAC: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
  • INCHI Name: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
  • INCHI Key: HVYWMOMLDIMFJA-DPAQBDIFSA-N
  • Molecular Weight: 386.7
  • Canonical SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
  • Isomeric SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
  • Molecular Formula: C27H46O

Compound Supplier

  • Supplier Name: Combi-Blocks
  • Catalog #: QE-3931
  • Lot #: B15201

Compound Characterization

  • HPLC-ELS: Tr 2.69 min.

Dose Response Curve

  • Platform ID: Cholesterol
  • Min: 11.1840; Max: 96.6964





IC Concentration (µM)
IC10 N/A
IC20 0.0001
IC30 0.0002
IC40 0.0004
IC50 0.0007
IC60 0.0011
IC70 0.0018
IC80 0.0036
IC90 0.0096


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/0ScoresViewViewViewViewView