Pfam Domains GO Terms
| tRNA-synt 1e |
| cysteine-tRNA ligase activity |
| cysteinyl-tRNA aminoacylation |
| tRNA aminoacylation for protein translation |
| tRNA aminoacylation |
| amino acid activation |
| tRNA binding |
| tRNA metabolic process |
| cellular amino acid metabolic process |
| translation |
| peptide biosynthetic process |
| ncRNA metabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| protein homodimerization activity |
| carboxylic acid metabolic process |
| oxoacid metabolic process |
| organic acid metabolic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| gene expression |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Gene | Correlation |
|---|---|
| HARS | 0.642 |
| MARS | 0.557 |
| HSPD1 | 0.523 |
| GMPPB | 0.511 |
| RNMT | 0.485 |
| GFPT1 | 0.481 |
| NARS | 0.477 |
| ALG2 | 0.474 |
| MEAF6 | 0.456 |
| NAE1 | 0.455 |
| CSNK2B | 0.448 |
| TSEN34 | 0.444 |
| SRP72 | 0.44 |
| RTCB | 0.44 |
| SMARCD1 | 0.437 |
| VMP1 | 0.436 |
| SPCS3 | 0.435 |
| ENY2 | 0.433 |
| EPRS | 0.431 |
| PMM2 | 0.429 |
| CCT7 | 0.427 |
| SLC35B1 | 0.426 |
| PAM16 | 0.425 |
| UBA3 | 0.425 |
| PELO | 0.424 |
| CASP9 | 0.422 |
| NSMCE2 | 0.421 |
| SEH1L | 0.42 |
| YARS | 0.419 |
| TRIAP1 | 0.418 |
| RPTOR | 0.418 |
| HSPA9 | 0.416 |
| CCDC101 | 0.415 |
| EIF4E | 0.415 |
| OTUD5 | 0.412 |
| APAF1 | 0.412 |
| AARS | 0.412 |
| ALG11 | 0.41 |
| UBE2L3 | 0.409 |
| MTOR | 0.408 |
| GTF3C3 | 0.407 |
| DHPS | 0.406 |
| MLLT1 | 0.404 |
| DPAGT1 | 0.403 |
| UAP1 | 0.4 |
| POLR3B | 0.4 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 24/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 73/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 23/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Expression Distribution