MMS22L
Gene Information
- Official Symbol: MMS22L
- Official Name: MMS22 like, DNA repair protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 253714
- UniProt: Q6ZRQ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 924
- Expression level (log2 read counts): 7.14
MMS22L Expression in NALM6 Cells: 7.14
