TSG101

Gene Information

Official Symbol: TSG101
Official Name: tumor susceptibility 101
Aliases and Previous Symbols: N/A
Entrez ID: 7251
UniProt: Q99816
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 1μM R00 exp19	-2.5
Pimelic-diphenylamide-106 5μM R00 exp28	-2.1
DABN racemic mixture R03 exp93	-2.03
5-Fluorouracil 20μM R00 exp2	-1.98
Nocodazole 0.2μM R02 exp64	-1.92
Vinblastine 0.2μM R03 exp108	-1.87
Salinomycin 3.5μM R08 exp521	-1.83
Atovaquone 15μM R08 exp451	-1.77
Dihydrosphingosine 8μM R08 exp476	1.71
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.78

Gene	Correlation
PSMB4	0.565
CHD4	0.553
TCEB3C	0.52
COPG1	0.516
CCNA2	0.511
NPIPB5	0.506
ATP6V1C1	0.503
TCEB3CL	0.493
DHX38	0.492
KRT78	0.492
KCTD17	0.492
RRP7A	0.49
UTP3	0.488
ZNF830	0.488
TCEB3CL2	0.485
LRR1	0.483
PAN3	0.477
TPX2	0.474
SUPT5H	0.474
ATP6AP1	0.473
RPS2	0.47
TBC1D3F	0.47
MT1E	0.467
C1QTNF9B	0.465
SKIV2L2	0.464
PAF1	0.464
NUPL1	0.463
CBWD3	0.462
NAPA	0.461
BRD2	0.461
TBC1D3G	0.461
SLC4A1	0.461
GOLGA6L1	0.46
ANKLE2	0.459
CTAGE4	0.458
PSMB2	0.458
DDX56	0.457
SH3BP1	0.457
CBWD5	0.457
XYLT2	0.457
DTL	0.456
PSMC5	0.455
TIMELESS	0.454
SF3A2	0.454
VPS28	0.45
POLE	0.449
GID4	0.445
PSMD3	0.445
PSMA6	0.445
ORC6	0.443
SF3A3	0.442
CACTIN	0.441
UPF1	0.441
TBC1D3	0.441
TBC1D3H	0.441
PSMD8	0.44
RANBP2	0.44
PRPF19	0.44
PSMD11	0.439
COPA	0.438
ATP6V1B2	0.437
CHAF1A	0.437
SEC13	0.437
ATP6V1A	0.436
CDCA3	0.436
EXOSC6	0.435
TP53TG3B	0.435
ORC1	0.435
NUP160	0.434
TP53TG3	0.434
COPE	0.434
TP53TG3C	0.433
PAN2	0.433
FAM25B	0.432
COX7A2L	0.43
GOLGA6L3	0.43
TRAPPC5	0.43
CTAGE9	0.43
EFTUD2	0.429
CGB2	0.429
DISP2	0.429
NARFL	0.428
POLR2D	0.427
GOLGA8O	0.427
PPM1D	0.427
CBWD6	0.427
SNIP1	0.426
COL2A1	0.425
RPS5	0.424
CEP192	0.423
MFSD12	0.423
CCDC64B	0.423
POLR2F	0.422
PSMD2	0.421
SLC6A17	0.421
C14orf93	0.421
TSPY8	0.42
FBXW9	0.419
PSMC1	0.418
PDCD7	0.418
VASN	0.417
SNRPA1	0.417
COPZ1	0.416
RFC1	0.416
EXOSC5	0.415
EIF4A3	0.415
ATXN1	0.415
CDC73	0.414
AAMP	0.414
MED14	0.414
OSBP	0.413
INTS5	0.412
TSPY1	0.411
TAF1	0.41
CACNA1A	0.41
SUPT6H	0.409
TRAPPC11	0.408
CDH24	0.408
DDTL	0.407
MTCH2	0.406
HIVEP3	0.405
EXD1	0.405
NELFCD	0.405
RPL35	0.404
SYT9	0.403
C2orf27B	0.403
RPS19	0.403
SSH2	0.402
CRNKL1	0.402
MPHOSPH10	0.401
EBNA1BP2	0.401
MAT2A	0.401
DOCK6	0.4

Global Fraction of Cell Lines Where Essential: 310/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	13/28
blood	15/28
bone	13/25
breast	16/33
central nervous system	15/56
cervix	4/4
colorectal	5/17
esophagus	4/13
fibroblast	0/1
gastric	9/15
kidney	6/21
liver	6/20
lung	26/75
lymphocyte	5/14
ovary	13/26
pancreas	7/24
peripheral nervous system	9/16
plasma cell	7/15
prostate	1/1
skin	13/24
soft tissue	4/7
thyroid	0/2
upper aerodigestive	13/22
urinary tract	17/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1461
Expression level (log2 read counts): 4.92

Expression Distribution