ELP2

Entrez Summary: The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 10μM R04 exp180	-1.93
S-DABN 8μM R03 exp112	-1.92
Vinblastine 0.002μM R01 exp60	-1.92
Docetaxel 0.002μM R01 exp45	-1.72
Artemisinin 50μM R08 exp450	1.72
Salubrinal 20μM R07 exp399	1.76
Chloramphenicol 20μM R00 exp13	1.77
Hippuristanol 0.12μM R08 exp488	1.92
UM0129480 7μM R02 exp85	1.97
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.1
Mubritinib 0.2μM R02 exp65	2.13
2-Deoxy-D-glucose 800μM R05 exp214	2.44
MS023 2μM R03 exp134	2.63
MS023 7μM R03 exp135	3.24

Global Fraction of Cell Lines Where Essential: 123/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	8/28
blood	2/28
bone	3/25
breast	6/33
central nervous system	11/56
cervix	0/4
colorectal	5/17
esophagus	3/13
fibroblast	0/1
gastric	3/15
kidney	7/21
liver	1/20
lung	13/75
lymphocyte	1/14
ovary	3/26
pancreas	5/24
peripheral nervous system	3/16
plasma cell	1/15
prostate	0/1
skin	12/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	5/22
urinary tract	5/29
uterus	1/5

Expression Distribution

Elongator holoenzyme complex
tRNA wobble uridine modification
tRNA wobble base modification
transcription elongation factor complex
RNA polymerase II complex binding
transcription elongation from RNA polymerase II promoter
tRNA modification
DNA-templated transcription, elongation
tRNA processing
RNA modification
tRNA metabolic process
ncRNA processing
ncRNA metabolic process
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression