Fluvastatin 2.2μM R06 exp282

Inhibits HMG-CoA reductase, decreases cholesterol biogenesis, upregulates LDL-receptors

PubChem Name: Fluvastatin sodium
Synonyms: XU 62320 sodium
CAS #: 93957-55-2
PubChem CID: 23663976
IUPAC: sodium;(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate
INCHI Name: InChI=1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m1./s1
INCHI Key: ZGGHKIMDNBDHJB-NRFPMOEYSA-M
Molecular Weight: 433.4
Canonical SMILES: CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+]
Isomeric SMILES: CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+]
Molecular Formula: C24H25FNNaO4

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
37/75	Scores	View	View	View	View	View

GO Term	Fold Change	Genes
COPII-coated vesicle cargo loading	126.84	SCAP,SEC31A,RAB1A
regulation of cholesterol biosynthetic process	98.65	SREBF2,MBTPS2,MBTPS1
regulation of sterol biosynthetic process	98.65	SCAP,MBTPS2,MBTPS1
ER-nucleus signaling pathway	98.65	SCAP,SREBF2,MBTPS2,MBTPS1,GSK3B
positive regulation of glycoprotein metabolic process	73.99	RAB1B,RAB1A,GOLGA2
regulation of cholesterol metabolic process	69.64	SCAP,SREBF2,MBTPS2,MBTPS1
regulation of alcohol biosynthetic process	49.33	SCAP,SREBF2,MBTPS2,MBTPS1
ER to Golgi transport vesicle membrane	40.13	SCAP,SREBF2,USO1,SEC31A
COPII-coated ER to Golgi transport vesicle	33.25	SCAP,SREBF2,USO1,SEC31A,GOLGA2
regulation of steroid biosynthetic process	32.43	SCAP,SREBF2,MBTPS2,MBTPS1
cholesterol metabolic process	30.88	SCAP,SREBF2,MBTPS2,SQLE,MBTPS1,HMGCR
endoplasmic reticulum to Golgi vesicle-mediated transport	28.41	SCAP,RAB1B,USO1,SEC31A,RAB1A,GOLGA2
secondary alcohol metabolic process	28.41	SCAP,SREBF2,MBTPS2,SQLE,MBTPS1,HMGCR
sterol metabolic process	27.75	SCAP,SREBF2,MBTPS2,SQLE,MBTPS1,HMGCR
Golgi organization	26.70	RAB1B,USO1,ARL1,COG7,RAB1A,GOLGA2
Golgi vesicle transport	19.37	SCAP,RAB1B,USO1,SLC10A7,COG7,PITPNB,SEC31A,RAB1A,GOLGA2
steroid metabolic process	14.09	SCAP,SREBF2,MBTPS2,SQLE,MBTPS1,HMGCR
Golgi membrane	12.63	UNC50,SCAP,ENTPD4,SREBF2,RAB1B,USO1,ARL1,MBTPS2,SLC10A7,COG7,PITPNB,MBTPS1,RAB1A,GOLGA2
Golgi apparatus subcompartment	11.38	SLC39A9,USO1,ARL1,SLC10A7,COG7,MBTPS1,GOLGA2

GO Term	Fold Change	Genes
GID complex	414.35	ARMC8,MAEA,RMND5A
protein import into peroxisome matrix, receptor recycling	276.23	PEX2,PEX1,PEX12
peroxisomal membrane transport	131.54	ABCD3,PEX2,PEX3,PEX1,PEX12
peroxisomal transport	120.10	ABCD3,PEX2,PEX3,PEX1,PEX12
protein targeting to peroxisome	116.31	PEX2,PEX3,PEX1,PEX12
retrograde protein transport, ER to cytosol	97.49	FAF2,HSP90B1,AUP1
endoplasmic reticulum to cytosol transport	97.49	FAF2,HSP90B1,AUP1
establishment of protein localization to peroxisome	87.23	PEX2,PEX1,PEX12
peroxisome organization	83.71	ABCD3,PEX2,PEX3,PEX1,PEX12
microbody membrane	51.79	ABCD3,ACSL3,PEX2,PEX3,PEX1,PEX12
peroxisomal membrane	51.79	ABCD3,ACSL3,PEX2,PEX3,PEX1,PEX12
microbody	27.04	ABCD3,HMGCL,ACSL3,PEX2,PEX3,PEX1,PEX12
peroxisome	27.04	ABCD3,HMGCL,ACSL3,PEX2,PEX3,PEX1,PEX12
proteasome-mediated ubiquitin-dependent protein catabolic process	12.81	FAF2,ARMC8,HSP90B1,MAEA,UBE2H,RMND5A,PEX12,AUP1
proteasomal protein catabolic process	11.63	FAF2,ARMC8,HSP90B1,MAEA,UBE2H,RMND5A,PEX12,AUP1
ubiquitin-dependent protein catabolic process	8.65	FAF2,ARMC8,HSP90B1,MAEA,UBE2H,RMND5A,PEX12,AUP1
modification-dependent protein catabolic process	8.48	FAF2,ARMC8,HSP90B1,MAEA,UBE2H,RMND5A,PEX12,AUP1
modification-dependent macromolecule catabolic process	8.31	FAF2,ARMC8,HSP90B1,MAEA,UBE2H,RMND5A,PEX12,AUP1
protein catabolic process	7.15	LDLR,FAF2,ARMC8,HSP90B1,MAEA,UBE2H,RMND5A,PEX12,AUP1