Hydroxychloroquine 30μM R08 exp490

Lysosomotropic agent, prevents sequestration of heme into hemozoin, forms toxic complex with heme, also inhibits TLR 7/9

Class / Subclass 1: Infectious Disease / Antimalarial
Class / Subclass 2: DNA Damage, Repair and Replication / Intercalating Agent
Class / Subclass 3: Proteostasis / Autophagy Inhibitor

PubChem Name: Hydroxychloroquine sulfate
Synonyms: HCQ sulfate
CAS #: 747-36-4
PubChem CID: 12947
IUPAC: 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid
INCHI Name: InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
INCHI Key: JCBIVZZPXRZKTI-UHFFFAOYSA-N
Molecular Weight: 434
Canonical SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
Isomeric SMILES: N/A
Molecular Formula: C18H28ClN3O5S

Characterization data not available.

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
9/0	Scores	View	View	View	View	View

Screen	Correlation	Plot
Thioridazine 5μM R08 exp530	0.096	View
NN-Dimethylsphingosine 2.5μM R08 exp508	0.095	View
Prochlorperazine 5.2μM R02 exp77	0.069	View
Chloroquine 32μM R08 exp470	0.098	View
FTY720 3μM R08 exp483	0.082	View
B02 10μM R08 exp453	0.063	View
Cannabidiol 13μM R08 exp465	0.061	View
Bisphenol F 50μM R08 exp457	0.059	View
Bafilomycin-A1 0.009μM R08 exp454	0.053	View
Azithromycin 100μM R08 exp452	0.052	View