TIMM22

Entrez Summary: N/A
UniProt Summary: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250|UniProtKB:Q12328}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.4μM R03 exp99	-2.2
A-395N 10μM R05 exp219	-2.18
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.88
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.88
Rifampicin 30μM R08 exp430	-1.81
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.8
Cerivastatin 0.15μM R05 exp226	-1.78
Tubacin 1.6μM R07 exp416	-1.77
Dynasore 10μM R04 exp180	-1.76
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.73
HMS-I1 1μM R01 exp46	-1.73
Quercetin 20μM R08 exp517	-1.72
GSK461364A 0.1μM R03 exp126	1.7
Etoposide 0.3μM R05 exp199	1.75
Vinblastine 0.015μM R05 exp208	1.79
Centrinone 0.5μM R07 exp343	1.86
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.9
Nocodazole 0.1μM R03 exp94	1.92
Benzoate 20000μM R08 exp456	1.96
Pimelic-diphenylamide-106 5μM R00 exp28	1.98
GSK-J4 1.5μM R08 exp441	2.03

Global Fraction of Cell Lines Where Essential: 17/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TIM22 mitochondrial import inner membrane insertion complex
mitochondrion targeting sequence binding
protein insertion into mitochondrial inner membrane
establishment of protein localization to mitochondrial membrane
protein transmembrane transporter activity
protein insertion into mitochondrial membrane
protein insertion into membrane
inner mitochondrial membrane organization
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial membrane organization
mitochondrial transport
establishment of protein localization to membrane
protein targeting
mitochondrial inner membrane
establishment of protein localization to organelle
mitochondrion organization
protein localization to membrane
protein localization to organelle
membrane organization
intracellular protein transport
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport