JTB

Entrez Summary: N/A
UniProt Summary: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250, ECO:0000269|PubMed:21225229}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.7
WYE-354 6μM R02 exp90	-2.59
Cannabidiol 20μM R08 exp466	-2.55
Cannabidiol 13μM R08 exp465	-2.52
Thioridazine 5μM R08 exp530	-2.46
Clomiphene 4.4μM R02 exp68	-2.33
Wortmannin 5μM R00 exp38	-2.28
Cryptotanshinone 12μM R05 exp227	-2.25
BS-181 20μM R08 exp461	-2.24
Cincreasin 100μM R08 exp473	-2.17
Monensin 0.3μM R08 exp507	-2.11
JQ1 0.8μM R08 exp435	-2.05
Bafilomycin-A1 0.009μM R08 exp454	-2.04
Vemurafenib 6.6μM R02 exp89	-2.04
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.03
MK2206 4μM R08 exp504	-1.96
Caffeine 2600μM R08 exp463	-1.89
Dihydrosphingosine 8μM R08 exp476	-1.88
L-74142 5μM R03 exp131	-1.83
Nicotine 3000μM R08 exp510	-1.82
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.81
B02 10μM R08 exp453	-1.73

Global Fraction of Cell Lines Where Essential: 4/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitotic cytokinesis
cytoskeleton-dependent cytokinesis
cytokinesis
spindle
midbody
protein kinase binding
centrosome
cell division
positive regulation of protein kinase activity
positive regulation of kinase activity
mitotic cell cycle process
positive regulation of transferase activity
mitotic cell cycle
regulation of protein kinase activity
regulation of kinase activity
apoptotic process
regulation of transferase activity
cell cycle process
positive regulation of protein phosphorylation
programmed cell death
positive regulation of phosphorylation
cell death
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
mitochondrion
cell cycle
integral component of plasma membrane
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
membrane