MDH1
Gene Information
- Official Symbol: MDH1
- Official Name: malate dehydrogenase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4190
- UniProt: P40925
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ldh 1 C |
| Ldh 1 N |
GO Terms
| diiodophenylpyruvate reductase activity |
| L-malate dehydrogenase activity |
| malic enzyme activity |
| malate metabolic process |
| oxaloacetate metabolic process |
| tricarboxylic acid cycle |
| NADH metabolic process |
| NAD binding |
| gluconeogenesis |
| NAD metabolic process |
| hexose biosynthetic process |
| monosaccharide biosynthetic process |
| aerobic respiration |
| dicarboxylic acid metabolic process |
| glucose metabolic process |
| carbohydrate biosynthetic process |
| hexose metabolic process |
| cellular respiration |
| monosaccharide metabolic process |
| energy derivation by oxidation of organic compounds |
| generation of precursor metabolites and energy |
| carbohydrate metabolic process |
| small molecule biosynthetic process |
| carboxylic acid metabolic process |
| oxidation-reduction process |
| oxoacid metabolic process |
| organic acid metabolic process |
| extracellular space |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16213
- Expression level (log2 read counts): 6.87
Expression Distribution
MDH1 Expression in NALM6 Cells: 6.87
