MEMO1

Entrez Summary: N/A
UniProt Summary: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
JQ1 0.8μM R08 exp435	-2.46
GSK-J4 1.5μM R08 exp441	-2.19
Hinokiflavone 12μM R08 exp487	-1.94
UM131593 0.2μM R03 exp106	-1.87
Monensin 0.3μM R08 exp507	-1.7
BI-D1870 3.15μM R02 exp66	1.76
KU-0063794 3.8μM R02 exp71	1.78
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.81
Dorsomorphin 5μM R07 exp357	1.82
Thimerosal 0.85μM R08 exp529	1.84
LY2090314 0.003μM R08 exp499	1.85
A-366 10μM R03 exp115	1.86
Selumetinib 20μM R02 exp81	1.86
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.91
EPZ-5676 30μM R05 exp233	1.93
Hippuristanol 0.12μM R08 exp488	1.94
VER-155008 3.9μM R06 exp301	2.05
Clomiphene 4.4μM R02 exp68	2.14
Azithromycin 100μM R08 exp452	2.19
Torin1 0.08μM R02 exp82	2.22
Ethanol 0.01 R05 exp234	2.26
Aminopterin 0.005μM R07 exp335	2.31
Dimethyloxaloylglycine 100μM R05 exp229	2.32
AICAR 240μM R03 exp116	2.33
Actinomycin-D 0.001μM R00 exp3	2.53
Arsenate 40μM R06 exp264	2.59
Bortezomib 0.005μM R00 exp6	2.84
Wortmannin 0.5μM R00 exp37	2.84
MK2206 4μM R08 exp504	2.86
Rapamycin 2μM R07 exp306	2.88
Lead acetate 2000μM R08 exp497	2.9
MS023 2μM R03 exp134	3.14
Etoposide 0.1μM R05 exp198	3.16
GSK626616 14μM R08 exp485	3.21
I-BRD9 4μM R07 exp365	3.25
Dimethyl-Sulfoxide 1pc R03 exp120	3.34
Rapamycin 0.001μM R08 exp429	3.43
Lead acetate 2000μM R08 exp498 no dilution day6	3.45
THZ531 0.225μM R08 exp444	3.54
Rapamycin 1μM R00 exp29	3.88
Rapamycin 10μM R00 exp30	4.68

Global Fraction of Cell Lines Where Essential: 4/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of microtubule-based process
regulation of cell motility
regulation of locomotion
regulation of cellular component movement