MRPL36
Gene Information
- Official Symbol: MRPL36
- Official Name: mitochondrial ribosomal protein L36
- Aliases and Previous Symbols: N/A
- Entrez ID: 64979
- UniProt: Q9P0J6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L36 |
GO Terms
| mitochondrial large ribosomal subunit |
| mitochondrial translational termination |
| mitochondrial translational elongation |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| protein-containing complex disassembly |
| nuclear body |
| ribosome biogenesis |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| ribonucleoprotein complex biogenesis |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| mitochondrion |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM131593 0.2μM R03 exp106 | 1.82 |
| WYE-354 6μM R02 exp90 | 1.91 |
| Deferoxamine 11μM R07 exp350 | 2.17 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HSD17B10 | 0.567 |
| COX16 | 0.56 |
| SUPV3L1 | 0.553 |
| MRPS6 | 0.544 |
| TARS2 | 0.532 |
| MRPS5 | 0.53 |
| SCO2 | 0.53 |
| MRPL21 | 0.521 |
| YARS2 | 0.518 |
| SLC25A26 | 0.516 |
| DAP3 | 0.516 |
| MRPS21 | 0.515 |
| SARS2 | 0.513 |
| SELRC1 | 0.512 |
| MRPL23 | 0.509 |
| MRPS34 | 0.507 |
| KIAA0391 | 0.499 |
| QRSL1 | 0.492 |
| MRPS14 | 0.491 |
| VARS2 | 0.489 |
| MRPS2 | 0.488 |
| RPUSD4 | 0.485 |
| MRPS18A | 0.484 |
| MTPAP | 0.483 |
| MRPL53 | 0.481 |
| MRPS16 | 0.48 |
| TUFM | 0.48 |
| DARS2 | 0.473 |
| MRPL20 | 0.471 |
| MRPS22 | 0.471 |
| FARS2 | 0.47 |
| GFM1 | 0.467 |
| MRPS12 | 0.467 |
| GTPBP10 | 0.466 |
| MRPS26 | 0.465 |
| MRPS23 | 0.462 |
| RBFA | 0.461 |
| MRP63 | 0.457 |
| MRPL33 | 0.455 |
| PARS2 | 0.454 |
| PNPT1 | 0.454 |
| MRPL12 | 0.453 |
| MRPL15 | 0.453 |
| NARS2 | 0.451 |
| MRPL3 | 0.441 |
| BCS1L | 0.44 |
| FASTKD5 | 0.44 |
| EARS2 | 0.439 |
| COA5 | 0.439 |
| LARS2 | 0.438 |
| WBSCR16 | 0.437 |
| MRPL39 | 0.436 |
| PMM2 | 0.432 |
| TRUB2 | 0.431 |
| MRPS9 | 0.43 |
| MRPL47 | 0.43 |
| COX7B | 0.428 |
| PPCS | 0.427 |
| PDSS1 | 0.427 |
| UQCRC2 | 0.426 |
| FTSJ2 | 0.424 |
| COA6 | 0.424 |
| TIMM8B | 0.423 |
| DHX30 | 0.422 |
| MARS2 | 0.419 |
| TRIAP1 | 0.419 |
| HARS2 | 0.418 |
| MRPL52 | 0.418 |
| CRLS1 | 0.416 |
| COX17 | 0.414 |
| AIFM1 | 0.412 |
| NDUFA3 | 0.412 |
| C12orf65 | 0.409 |
| MRPL42 | 0.408 |
| AASDHPPT | 0.407 |
| GFM2 | 0.403 |
| MRPS10 | 0.402 |
| MRPL55 | 0.401 |
| NDUFB5 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 23/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 1/28 |
| bone | 1/26 |
| breast | 3/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 1/21 |
| liver | 1/20 |
| lung | 1/75 |
| lymphocyte | 2/16 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2177
- Expression level (log2 read counts): 4.68
Expression Distribution
MRPL36 Expression in NALM6 Cells: 4.68