POLR2J2

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-2.43
IWR1 50μM R08 exp495	-2.26
Brefeldin A 0.02μM R00 exp8	-2.1
Rapamycin 2μM R07 exp306	-2.06
Palbociclib 1μM R07 exp382	-1.99
Pimelic-diphenylamide-106 5μM R00 exp28	-1.84
MLN-4924 2μM R00 exp22	-1.74
IL-3 9ng/ml R08 exp493	1.76
Nicotinamide 1000μM R03 exp101	1.84
CAY10603 0.55μM R08 exp467	1.85
RK-33 8μM R08 exp518	1.96
HMS-I1 1μM R01 exp46	2.03
BI-2536 0.001μM R01 exp41	2.11
Apcin 25μM plus proTAME 2μM R04 exp177	2.12
FK-506 30μM R07 exp359	2.19
Taxol 0.002μM R01 exp54	2.22
GSK591 2.6μM R03 exp128	2.26
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	2.38
B02 10μM R08 exp453	2.39
LLY-284 2.6μM R06 exp291	2.48

Expression Distribution

RNA polymerase II activity
RNA polymerase II, core complex
DNA-directed 5-3 RNA polymerase activity
protein dimerization activity
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression