PTDSS1
Gene Information
- Official Symbol: PTDSS1
- Official Name: phosphatidylserine synthase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9791
- UniProt: P48651
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014].
- UniProt Summary: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4027
- Expression level (log2 read counts): 7.07
PTDSS1 Expression in NALM6 Cells: 7.07
