RALGAPB

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-3.62
Vemurafenib 6.6μM R08 exp434	-3.54
Clomiphene 4.4μM R02 exp68	-3.45
GSK461364A 0.005μM R03 exp125	-3.38
Vemurafenib 6.6μM R02 exp89	-3.24
BH1 1μM R04 exp169	-2.9
Bafilomycin-A1 0.009μM R08 exp454	-2.68
Thioridazine 5μM R08 exp530	-2.36
YM155 0.001μM R08 exp432	-2.34
Tubacin 1.6μM R07 exp416	-2.17
Caffeine 2600μM R08 exp463	-2.05
Cadmium 60μM R08 exp462	-2.01
BI-6727 0.0125μM R03 exp97	-1.93
Bisphenol F 50μM R08 exp457	-1.9
Dynasore 10μM R04 exp180	-1.9
CR131-b 0.005μM R08 exp474	-1.89
Apcin 25μM plus proTAME 2μM R04 exp177	-1.87
Cannabidiol 13μM R08 exp465	-1.84
WYE-354 6μM R02 exp90	-1.77
CCCP 0.1μM R00 exp10	-1.71
Nifuroxazide 1μM R01 exp51	-1.71
Palbociclib 1μM R07 exp382	1.72
Oligomycin-A 20μM R00 exp26	1.81
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.84
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.91
Lead acetate 2000μM R08 exp497	2
Sulforaphane 9μM R08 exp526 no dilution day6	2.03
Mdivi-1 15μM R05 exp217	2.09
CCT251545 20μM R07 exp326	2.14
Diepoxybutane 3μM R07 exp354	2.15
Deguelin 0.15μM R05 exp209	2.17
BML-284 0.09μM R08 exp460	2.22
Aminopterin 0.005μM R07 exp335	2.28
LB-100 4.1μM R02 exp72	2.29
Colchicine 0.009μM R05 exp215	2.32
Tozasertib 0.1μM R07 exp414	2.32
LJH685 50μM R08 exp433	2.39
Lead acetate 2000μM R08 exp498 no dilution day6	2.51
Cytochalasin-B 5μM R07 exp349	2.63
iCRT14 30μM R08 exp492	2.82
Demecolcine 0.03μM R05 exp228	2.89
Latrunculin-B 10μM R07 exp374	3.05
UM131593 0.2μM R03 exp106	3.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

activation of GTPase activity
GTPase activator activity
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of GTPase activity
protein heterodimerization activity
positive regulation of hydrolase activity
regulation of hydrolase activity
positive regulation of catalytic activity
positive regulation of molecular function
regulation of intracellular signal transduction