TACC3

Entrez Summary: N/A
UniProt Summary: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 0.6μM R03 exp107	-4.25
Taxol 0.004μM R03 exp103	-3.81
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-3.48
Demecolcine 0.03μM R05 exp228	-3.48
Colchicine 0.009μM R05 exp215	-3.4
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-3.25
Taxol 0.002μM R01 exp54	-2.96
Mdivi-1 15μM R05 exp217	-2.93
BML-284 0.09μM R08 exp460	-2.91
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.83
Docetaxel 0.002μM R01 exp45	-2.61
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.58
Cabazitaxel 0.001μM R05 exp223	-2.5
Quercetin 20μM R08 exp517	-2.5
UMK57 1μM R01 exp59	-2.41
UM131593 0.1μM R01 exp58	-2.38
Epothilone-B 0.0015μM R05 exp231	-2.32
Sulforaphane 9μM R08 exp525	-2.28
Vincristine 0.0005μM R04 exp190	-2.27
HMS-I1 1μM R01 exp46	-2.19
Sulforaphane 9μM R08 exp526 no dilution day6	-2.13
2-Methoxyestradiol 0.55μM R07 exp310	-2.11
UM131593 0.2μM R03 exp106	-1.99
S-trityl-L-cysteine 0.5μM R05 exp243	-1.98
Thimerosal 0.85μM R08 exp529	-1.89

Global Fraction of Cell Lines Where Essential: 77/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	0/28
bone	2/26
breast	3/33
central nervous system	6/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	2/21
liver	1/20
lung	6/75
lymphocyte	2/16
ovary	6/26
pancreas	3/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	1/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	9/22
urinary tract	4/29
uterus	2/5

Expression Distribution

metaphase/anaphase transition of mitotic cell cycle
metaphase/anaphase transition of cell cycle
regulation of mitotic spindle organization
regulation of spindle organization
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
mitotic spindle organization
mitotic spindle
regulation of sister chromatid segregation
regulation of chromosome segregation
microtubule cytoskeleton organization involved in mitosis
cerebral cortex development
spindle pole
spindle organization
microtubule organizing center
regulation of mitotic nuclear division
pallium development
regulation of microtubule cytoskeleton organization
regulation of nuclear division
regulation of microtubule-based process
telencephalon development
mitotic cell cycle phase transition
cell cycle phase transition
regulation of chromosome organization
forebrain development
microtubule cytoskeleton organization
cell division
regulation of cytoskeleton organization
cell population proliferation
mitotic cell cycle process
regulation of mitotic cell cycle
microtubule-based process
mitotic cell cycle
brain development
regulation of cell cycle process
head development
central nervous system development
cell cycle process
cytoskeleton organization