ZFY

Entrez Summary: This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008].
UniProt Summary: Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'. {ECO:0000269|PubMed:20028140}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-3.38
MK2206 4μM R08 exp504	-2.85
Vemurafenib 6.6μM R02 exp89	-2.54
Rapamycin 0.001μM R08 exp429	-2.3
Vemurafenib 6.6μM R08 exp434	-2.14
All-trans-Retinoic-Acid 8μM R07 exp333	-2.13
Bafilomycin-A1 0.009μM R08 exp454	-2.11
Trametinib 10μM R02 exp83	-2.06
I-BRD9 4μM R07 exp365	-1.99
Ethanol 0.01 R05 exp234	-1.94
S-trityl-L-cysteine 0.5μM R05 exp243	-1.92
Selumetinib 20μM R02 exp81	-1.89
Clomiphene 4.4μM R02 exp68	-1.78
Demecolcine 0.03μM R05 exp228	-1.75
Senexin-A 25μM R07 exp400	-1.75
Colchicine 0.009μM R05 exp215	-1.74
Thapsigargin 0.005μM R07 exp407	-1.74
HMS-I1 1μM R01 exp46	-1.73
Oligomycin-A 2μM R00 exp25	-1.7
AICAR 240μM R03 exp116	1.72
SB202190 10μM R03 exp148	1.74
Latrunculin-B 10μM R07 exp374	1.77
Benzoate 20000μM R08 exp456	1.81
A-196 10μM R03 exp114	1.87
BI-2536 0.02μM R03 exp96	1.87
PNU96415E 10μM R03 exp145	1.92
MLN-4924 0.2μM R00 exp21	2.02
GSK-J4 1-1.25μM to day4 R07 exp363	2.04
MS023 7μM R03 exp135	2.08
QNZ 0.01μM R08 exp439	2.08
ML-792 0.2μM R08 exp505	2.2
Erlotinib 10μM R05 exp216	2.37
Staurosporine 0.02μM R08 exp524	2.51
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.68
Nifuroxazide 5μM R03 exp102	2.73
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.75
THZ531 0.225μM R08 exp444	3.82

Expression Distribution

nucleolus
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific