ARFRP1

Gene Information

Official Symbol: ARFRP1
Official Name: ADP ribosylation factor related protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 10139
UniProt: Q13795
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. {ECO:0000250|UniProtKB:Q8BXL7}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Monensin 0.3μM R08 exp507	-3.29
Tubacin 1.6μM R07 exp416	-2.68
Cryptotanshinone 12μM R05 exp227	-2.55
BS-181 20μM R08 exp461	-2.54
Vemurafenib 6.6μM R08 exp434	-2.53
Vemurafenib 6.6μM R02 exp89	-2.49
LJH685 50μM R08 exp433	-2.41
Cisplatin 0.35μM R06 exp273	-2.28
Wiskostatin 3μM R07 exp422	-2.27
JQ1 0.8μM R08 exp435	-2.26
Bafilomycin-A1 0.009μM R08 exp454	-2.25
MS023 2μM R03 exp134	-2.22
Trametinib 10μM R02 exp83	-2.21
Etoposide 1μM R00 exp19	-2.19
Epothilone-B 0.0015μM R05 exp231	-2.18
Ibrutinib 1μM R07 exp372	-2.18
BI-D1870 3.15μM R02 exp66	-2.13
Nicotine 3000μM R08 exp510	-2.11
I-BRD9 4μM R07 exp365	-2.08
Thimerosal 0.85μM R08 exp529	-2.08
AICAR 240μM R03 exp116	-2.06
PU-H71 1μM R08 exp515	-2.06
LLY-283 2.6μM R06 exp290	-2.05
Salubrinal 20μM R07 exp399	-2.04
MLN-4924 0.2μM R00 exp21	-2.03
Aphidicolin 0.4μM R08 exp440	-2
GSK461364A 0.1μM R03 exp126	-2
Nocodazole 0.2μM R00 exp24	-1.98
CR131-b 0.005μM R08 exp474	-1.96
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.96
Bisphenol F 50μM R08 exp457	-1.94
Clomiphene 4.4μM R02 exp68	-1.94
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.93
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.89
Tenofovir 10μM R07 exp405	-1.88
VER-155008 3.9μM R06 exp301	-1.88
Ribavirin 10 to 15μM on day4 R04 exp160	-1.87
42°C R08 exp539	-1.86
CB-5083 0.4μM R08 exp468	-1.84
MK2206 4μM R08 exp504	-1.84
Chlorpromazine 10μM R07 exp344	-1.83
Fluvastatin 2.2μM R06 exp282	-1.83
WYE-354 6μM R02 exp90	-1.83
A-395N 10μM R05 exp219	-1.82
All-trans-Retinoic-Acid 40μM R07 exp334	-1.82
Resminostat 0.5μM R07 exp393	-1.82
Thioridazine 5μM R08 exp530	-1.82
All-trans-Retinoic-Acid 8μM R07 exp333	-1.81
CFI-400945 25μM R08 exp469	-1.81
Latrunculin-B 10μM R07 exp374	-1.81
Tanespimycin 14μM R08 exp527	-1.81
Bisphenol A 100μM R06 exp269	-1.78
Genistein 15μM R07 exp360	-1.78
QNZ 0.01μM R05 exp241	-1.78
UM0011500 10μM R05 exp246	-1.78
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.76
BRD2 inhibitor II 20μM R07 exp341	-1.74
Docosahexaenoic-acid 50μM R07 exp356	-1.73
Vinorelbine 0.001μM R05 exp249	-1.72
DABN racemic mixture R03 exp93	-1.71
Doxorubicin 0.02μM R08 exp478	-1.71

Gene	Correlation
POLR2J3	0.47
JTB	0.451

Global Fraction of Cell Lines Where Essential: 72/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	5/26
breast	2/33
central nervous system	3/56
cervix	2/4
colorectal	0/17
esophagus	1/13
fibroblast	1/1
gastric	0/16
kidney	1/21
liver	6/20
lung	7/75
lymphocyte	3/16
ovary	2/26
pancreas	1/24
peripheral nervous system	4/16
plasma cell	3/15
prostate	0/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 921
Expression level (log2 read counts): 4.96

Expression Distribution