NDUFB2

Gene Information

Official Symbol: NDUFB2
Official Name: N/ADH:ubiquinone oxidoreductase subunit B2
Aliases and Previous Symbols: N/A
Entrez ID: 4708
UniProt: O95178
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Demecolcine 0.03μM R05 exp228	1.72
UM0125461 0.74μM R02 exp84	1.77
Artemisinin 50μM R08 exp450	1.99
Cannabidiol 20μM R08 exp466	2
Genistein 15μM R07 exp360	2.16
Atovaquone 15μM R08 exp451	2.26
Oligomycin-A 2μM R00 exp25	2.55

Gene	Correlation
NDUFA2	0.598
NDUFB11	0.576
NDUFA11	0.571
NUBPL	0.566
NDUFS2	0.553
GRSF1	0.552
ECSIT	0.547
ACAD9	0.545
NDUFB9	0.537
NDUFA1	0.526
NDUFAF3	0.52
NDUFAF7	0.517
NDUFA8	0.515
NDUFC2	0.511
NDUFB6	0.501
NDUFS8	0.5
MTO1	0.498
NDUFB10	0.494
NDUFAF6	0.492
TIMMDC1	0.492
NDUFA3	0.492
NDUFB5	0.488
NDUFC1	0.482
NDUFS5	0.48
PET117	0.479
MTRF1L	0.478
NDUFA10	0.476
RTN4IP1	0.475
NDUFA6	0.471
NDUFV2	0.471
CHCHD1	0.469
NDUFS3	0.465
GTPBP10	0.459
NDUFS7	0.456
COQ2	0.452
NDUFV1	0.45
FASTKD2	0.449
HMGXB3	0.444
NDUFB7	0.44
MTG1	0.438
MIPEP	0.431
METTL17	0.431
FOXRED1	0.43
NDUFB4	0.43
RBFA	0.428
C17orf89	0.426
NDUFA13	0.425
NFU1	0.425
GLRX5	0.424
PET112	0.422
NDUFB3	0.421
IBA57	0.421
MRPS21	0.419
MRPL55	0.419
RNASEH1	0.418
ATP5SL	0.417
MRPL15	0.413
MCAT	0.411
C12orf65	0.411
POLG2	0.41
FTSJ2	0.41
MRPL1	0.41
PTCD1	0.408
MRPL21	0.403
COQ7	0.403
NOA1	0.402
MRPL45	0.402
NDUFAF5	0.402
SELRC1	0.402
NDUFAF1	0.401
MTERFD1	0.4

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1903
Expression level (log2 read counts): 5.45

Expression Distribution