NUP54
Gene Information
- Official Symbol: NUP54
- Official Name: nucleoporin 54
- Aliases and Previous Symbols: N/A
- Entrez ID: 53371
- UniProt: Q7Z3B4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70582}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| protein localization to nuclear inner membrane |
| nuclear pore central transport channel |
| protein localization to nuclear envelope |
| protein heterotrimerization |
| nuclear pore organization |
| NLS-bearing protein import into nucleus |
| structural constituent of nuclear pore |
| protein heterotetramerization |
| tRNA-containing ribonucleoprotein complex export from nucleus |
| tRNA export from nucleus |
| tRNA transport |
| ncRNA export from nucleus |
| protein trimerization |
| intracellular transport of virus |
| host cell |
| regulation of protein import into nucleus |
| transport of virus |
| regulation of protein import |
| protein sumoylation |
| multi-organism localization |
| multi-organism transport |
| regulation of cellular response to heat |
| regulation of glycolytic process |
| regulation of gene silencing by miRNA |
| regulation of carbohydrate catabolic process |
| regulation of posttranscriptional gene silencing |
| regulation of gene silencing by RNA |
| protein import into nucleus |
| regulation of nucleocytoplasmic transport |
| protein heterooligomerization |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| mRNA export from nucleus |
| import into nucleus |
| viral transcription |
| regulation of protein localization to nucleus |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| viral gene expression |
| regulation of gene silencing |
| nucleus organization |
| protein import |
| protein export from nucleus |
| protein tetramerization |
| mRNA transport |
| regulation of generation of precursor metabolites and energy |
| nuclear export |
| protein localization to nucleus |
| nuclear envelope |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| viral life cycle |
| regulation of carbohydrate metabolic process |
| RNA localization |
| regulation of intracellular protein transport |
| nuclear membrane |
| nucleobase-containing compound transport |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| peptidyl-lysine modification |
| protein homooligomerization |
| regulation of intracellular transport |
| protein targeting |
| regulation of small molecule metabolic process |
| establishment of protein localization to organelle |
| protein localization to membrane |
| protein complex oligomerization |
| regulation of cellular protein localization |
| viral process |
| regulation of protein transport |
| protein localization to organelle |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| peptidyl-amino acid modification |
| regulation of cellular localization |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| intracellular protein transport |
| regulation of protein localization |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cannabidiol 20μM R08 exp466 | -1.81 |
| Mitomycin-C 0.06μM R08 exp503 | -1.7 |
| A-395 10μM R05 exp218 | 1.99 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| VASN | 0.536 |
| MYLK3 | 0.511 |
| PSMD1 | 0.502 |
| KCTD17 | 0.483 |
| TCEB3CL2 | 0.482 |
| MT1E | 0.479 |
| LRR1 | 0.476 |
| AKIRIN2 | 0.476 |
| DDTL | 0.475 |
| PSMA6 | 0.47 |
| C1QTNF9B | 0.469 |
| ORC1 | 0.468 |
| TCEB3C | 0.464 |
| NDC1 | 0.463 |
| RPS12 | 0.459 |
| TCEB3CL | 0.458 |
| NUP188 | 0.457 |
| C14orf93 | 0.456 |
| SSH2 | 0.456 |
| TBC1D3G | 0.456 |
| TBC1D3F | 0.454 |
| NUPL1 | 0.452 |
| TBC1D3H | 0.449 |
| CCNA2 | 0.448 |
| ORC6 | 0.448 |
| ATP13A1 | 0.448 |
| ELMOD3 | 0.447 |
| PSMB2 | 0.446 |
| COPG1 | 0.442 |
| PSMD3 | 0.442 |
| S1PR4 | 0.439 |
| IGFN1 | 0.438 |
| OGFR | 0.436 |
| HAUS3 | 0.435 |
| EXD1 | 0.435 |
| AHCTF1 | 0.434 |
| PSMD11 | 0.432 |
| SNRPA1 | 0.429 |
| PSMA7 | 0.428 |
| HMGCR | 0.428 |
| RPS2 | 0.427 |
| EIF4A3 | 0.426 |
| APRT | 0.425 |
| CHD4 | 0.424 |
| RRN3 | 0.423 |
| BCL2L1 | 0.42 |
| AAAS | 0.42 |
| SCAF1 | 0.419 |
| HIST2H3C | 0.418 |
| HIST2H3A | 0.418 |
| CDC6 | 0.418 |
| RPS3 | 0.416 |
| SUPT5H | 0.416 |
| TBC1D3 | 0.415 |
| RPSA | 0.414 |
| GOLGA6L6 | 0.413 |
| CDCA3 | 0.412 |
| AQR | 0.412 |
| PSMD14 | 0.412 |
| PSMC6 | 0.411 |
| PLA2G4F | 0.411 |
| PSMD6 | 0.411 |
| SUPT6H | 0.411 |
| INTS5 | 0.41 |
| NPIPB8 | 0.409 |
| POLR2F | 0.409 |
| TBC1D3E | 0.408 |
| TBC1D3K | 0.408 |
| TBC1D3I | 0.407 |
| ZFAND5 | 0.407 |
| TBC1D3L | 0.407 |
| RBM39 | 0.405 |
| KPNB1 | 0.405 |
| DDX56 | 0.405 |
| PSMD2 | 0.403 |
| PSMB1 | 0.403 |
| SEC13 | 0.403 |
| RSPH1 | 0.403 |
| ATXN1 | 0.402 |
| TFIP11 | 0.402 |
| MYT1L | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 308/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 10/28 |
| blood | 10/28 |
| bone | 13/26 |
| breast | 14/33 |
| central nervous system | 34/56 |
| cervix | 2/4 |
| colorectal | 5/17 |
| esophagus | 7/13 |
| fibroblast | 1/1 |
| gastric | 6/16 |
| kidney | 6/21 |
| liver | 9/20 |
| lung | 26/75 |
| lymphocyte | 10/16 |
| ovary | 13/26 |
| pancreas | 6/24 |
| peripheral nervous system | 3/16 |
| plasma cell | 12/15 |
| prostate | 0/1 |
| skin | 11/24 |
| soft tissue | 1/9 |
| thyroid | 2/2 |
| upper aerodigestive | 6/22 |
| urinary tract | 10/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 685
- Expression level (log2 read counts): 5.89
Expression Distribution
NUP54 Expression in NALM6 Cells: 5.89
