GAK
Gene Information
- Official Symbol: GAK
- Official Name: cyclin G associated kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 2580
- UniProt: O14976
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. {ECO:0000269|PubMed:10625686}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
| PTEN C2 |
| DnaJ |
GO Terms
| clathrin-coated pit assembly |
| synaptic vesicle uncoating |
| clathrin coat disassembly |
| vesicle uncoating |
| Golgi to lysosome transport |
| Golgi to vacuole transport |
| clathrin-dependent endocytosis |
| protein localization to Golgi apparatus |
| cyclin binding |
| chaperone cofactor-dependent protein refolding |
| protein depolymerization |
| de novo posttranslational protein folding |
| clathrin binding |
| de novo protein folding |
| synaptic vesicle endocytosis |
| presynaptic endocytosis |
| synaptic vesicle recycling |
| endoplasmic reticulum organization |
| chaperone-mediated protein folding |
| presynapse |
| post-Golgi vesicle-mediated transport |
| chaperone binding |
| lysosomal transport |
| synaptic vesicle cycle |
| vesicle-mediated transport in synapse |
| Golgi organization |
| cellular protein complex disassembly |
| vesicle |
| vacuolar transport |
| cytosolic transport |
| negative regulation of neuron projection development |
| negative regulation of cell projection organization |
| protein localization to plasma membrane |
| negative regulation of neuron differentiation |
| protein localization to cell periphery |
| protein folding |
| receptor-mediated endocytosis |
| protein-containing complex disassembly |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| negative regulation of cell development |
| protein serine/threonine kinase activity |
| Golgi vesicle transport |
| cellular component disassembly |
| focal adhesion |
| endomembrane system organization |
| protein localization to membrane |
| regulation of neuron projection development |
| endocytosis |
| regulation of neuron differentiation |
| import into cell |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| protein localization to organelle |
| regulation of neurogenesis |
| membrane organization |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| protein phosphorylation |
| Golgi apparatus |
| negative regulation of multicellular organismal process |
| phosphorylation |
| cell cycle |
| ATP binding |
| intracellular transport |
| generation of neurons |
| cellular protein localization |
| cellular macromolecule localization |
| neurogenesis |
| regulation of cell differentiation |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 20/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 1/16 |
| ovary | 1/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 1/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2114
- Expression level (log2 read counts): 6.87
Expression Distribution
GAK Expression in NALM6 Cells: 6.87
