MRPL35
Gene Information
- Official Symbol: MRPL35
- Official Name: mitochondrial ribosomal protein L35
- Aliases and Previous Symbols: N/A
- Entrez ID: 51318
- UniProt: Q9NZE8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L35p |
GO Terms
| mitochondrial ribosome |
| mitochondrial large ribosomal subunit |
| mitochondrial translational termination |
| mitochondrial translational elongation |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| protein-containing complex disassembly |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| mitochondrion |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0125461 0.74μM R02 exp84 | 1.77 |
| AICAR 240μM R05 exp211 | 1.81 |
| Oligomycin-A 2μM R00 exp25 | 1.84 |
| PU-H71 1μM R08 exp515 | 1.92 |
| Monensin 0.3μM R08 exp507 | 2.08 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| NARS2 | 0.523 |
| MRPS21 | 0.503 |
| MARS2 | 0.491 |
| MRPS35 | 0.486 |
| COA3 | 0.482 |
| MRPS6 | 0.473 |
| YARS2 | 0.471 |
| PET117 | 0.47 |
| MRPS26 | 0.469 |
| EARS2 | 0.463 |
| MRPS22 | 0.461 |
| GFM1 | 0.459 |
| VARS2 | 0.458 |
| SELRC1 | 0.457 |
| HSD17B10 | 0.453 |
| MRPS34 | 0.453 |
| MRPS16 | 0.452 |
| MRPS5 | 0.447 |
| LARS2 | 0.442 |
| TARS2 | 0.44 |
| MRPL43 | 0.438 |
| SCO2 | 0.436 |
| MRP63 | 0.436 |
| MRPL21 | 0.435 |
| TOMM20 | 0.434 |
| MRPS10 | 0.433 |
| MRPL28 | 0.433 |
| DDX28 | 0.43 |
| TEFM | 0.43 |
| QRSL1 | 0.429 |
| MRPL17 | 0.428 |
| TFB1M | 0.425 |
| RPUSD4 | 0.425 |
| DARS2 | 0.424 |
| COA6 | 0.423 |
| PET112 | 0.421 |
| FTSJ2 | 0.421 |
| DAP3 | 0.42 |
| NDUFS2 | 0.418 |
| MRPL9 | 0.415 |
| PTCD3 | 0.415 |
| MRPL47 | 0.413 |
| MRPL44 | 0.412 |
| MRPL3 | 0.412 |
| MTERFD1 | 0.411 |
| AIFM1 | 0.411 |
| MRPS14 | 0.41 |
| NDUFAF7 | 0.41 |
| CARS2 | 0.409 |
| AARS2 | 0.409 |
| MRPL20 | 0.408 |
| MRPS18A | 0.406 |
| COX16 | 0.405 |
| MTG2 | 0.404 |
| PARS2 | 0.404 |
| POLG2 | 0.403 |
| MRPL55 | 0.402 |
| HARS2 | 0.402 |
| NDUFA3 | 0.401 |
| POLRMT | 0.401 |
| RARS2 | 0.401 |
| NDUFC2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 32/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 3/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 2/21 |
| liver | 1/20 |
| lung | 5/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1394
- Expression level (log2 read counts): 5.92
Expression Distribution
MRPL35 Expression in NALM6 Cells: 5.92
