PPCDC
Gene Information
- Official Symbol: PPCDC
- Official Name: phosphopantothenoylcysteine decarboxylase
- Aliases and Previous Symbols: N/A
- Entrez ID: 60490
- UniProt: Q96CD2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:15581364}.
Pfam Domains GO Terms
Pfam Domains
| Flavoprotein |
GO Terms
| phosphopantothenoylcysteine decarboxylase activity |
| coenzyme A biosynthetic process |
| coenzyme A metabolic process |
| ribonucleoside bisphosphate biosynthetic process |
| purine nucleoside bisphosphate biosynthetic process |
| nucleoside bisphosphate biosynthetic process |
| purine nucleoside bisphosphate metabolic process |
| nucleoside bisphosphate metabolic process |
| ribonucleoside bisphosphate metabolic process |
| coenzyme biosynthetic process |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| cofactor biosynthetic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| purine-containing compound metabolic process |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| carbohydrate derivative biosynthetic process |
| organophosphate metabolic process |
| carbohydrate derivative metabolic process |
| identical protein binding |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PMVK | 0.722 |
| PGM3 | 0.636 |
| DNLZ | 0.614 |
| TRMT61A | 0.613 |
| DHRSX | 0.608 |
| TRMT6 | 0.569 |
| SRD5A3 | 0.566 |
| PPCS | 0.539 |
| METTL1 | 0.529 |
| TEN1 | 0.52 |
| LSM10 | 0.516 |
| FH | 0.506 |
| PTAR1 | 0.503 |
| RFT1 | 0.502 |
| PPA1 | 0.498 |
| RPIA | 0.493 |
| GEMIN6 | 0.491 |
| THG1L | 0.487 |
| FKBPL | 0.483 |
| GEMIN8 | 0.482 |
| YARS2 | 0.468 |
| PTPMT1 | 0.467 |
| GEMIN7 | 0.466 |
| C1D | 0.464 |
| DOLK | 0.463 |
| DDX39A | 0.463 |
| N6AMT1 | 0.461 |
| PPP6C | 0.459 |
| G6PD | 0.456 |
| PUS3 | 0.456 |
| MRPL21 | 0.453 |
| TUBE1 | 0.452 |
| NARS2 | 0.452 |
| RABGGTB | 0.452 |
| ALG6 | 0.449 |
| DAP3 | 0.445 |
| PARS2 | 0.445 |
| RPP21 | 0.445 |
| TSEN15 | 0.444 |
| SEPSECS | 0.442 |
| NBN | 0.442 |
| ATXN10 | 0.441 |
| MSTO1 | 0.44 |
| HSD17B10 | 0.44 |
| TUBD1 | 0.44 |
| RFK | 0.44 |
| C15orf41 | 0.438 |
| ZRSR2 | 0.43 |
| ZCRB1 | 0.43 |
| LARS2 | 0.427 |
| TPK1 | 0.425 |
| ALG1 | 0.425 |
| TMEM242 | 0.424 |
| EARS2 | 0.423 |
| KDSR | 0.422 |
| CXorf56 | 0.422 |
| SRP14 | 0.422 |
| TTC4 | 0.421 |
| SELRC1 | 0.421 |
| CEP57 | 0.421 |
| PPA2 | 0.42 |
| MRPS5 | 0.419 |
| TAMM41 | 0.416 |
| ELP6 | 0.415 |
| GEMIN4 | 0.414 |
| ATIC | 0.412 |
| AASDHPPT | 0.411 |
| SSB | 0.41 |
| GATC | 0.409 |
| MRPS6 | 0.409 |
| DOHH | 0.406 |
| PGS1 | 0.405 |
| TKT | 0.404 |
| MRE11A | 0.403 |
| SCO2 | 0.401 |
| PSMG2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 14/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 3/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 887
- Expression level (log2 read counts): 3.34
Expression Distribution
PPCDC Expression in NALM6 Cells: 3.34
