SNAPC5
Gene Information
- Official Symbol: SNAPC5
- Official Name: small nuclear RNA activating complex polypeptide 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 10302
- UniProt: O75971
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016].
- UniProt Summary: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 947
- Expression level (log2 read counts): 3.83
SNAPC5 Expression in NALM6 Cells: 3.83
