UM131593 0.2μM R03 exp106

UM131593 0.2μM R03 exp106

Mechanism of Action

Unknown

Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit

Technical Notes

Protein References

PubChem Name: N/A
Synonyms: N/A
CAS #: N/A
PubChem CID: N/A
IUPAC: N/A
INCHI Name: N/A
INCHI Key: N/A
Molecular Weight: 381.45
Canonical SMILES: N/A
Isomeric SMILES: N/A
Molecular Formula: C21H19NO4S

Protein Supplier

Supplier Name: In house - University of Montreal - Chemistry Platform
Catalog #: N/A
Lot #: IRIC-004 / sj2182-084 / Batch #01

Protein Characterization

Characterization data not available.

Dose Response Curve

Platform ID: UM0131593
Min: 0.7950; Max: 83.0421

IC	Concentration (µM)
IC10	N/A
IC20	0.0217
IC30	0.0436
IC40	0.0772
IC50	0.1304
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 200nM
Days of incubation: 8
Doublings: 1.2
Numbers of reads: 12428553

Screen Results

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
8/138	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
PDS5B	-3.20	<0.01
PCGF1	-3.19	<0.01
ITFG2	-2.86	0.02
GNL2	-2.84	0.03
RPL18	-2.74	0.34
LRRC8A	-2.74	0.02
ENO2	-2.61	0.05
TUBGCP2	-2.60	0.05
WAPAL	-2.58	0.11
KATNA1	-2.55	0.05
HEXIM1	-2.51	0.05
DLGAP5	-2.49	0.05
MSI2	-2.46	0.05
CENPW	-2.37	0.12
SKIV2L2	-2.36	0.22
PSTK	-2.36	0.08
FAM120A	-2.34	0.08
TNRC6C	-2.24	0.15
RING1	-2.24	0.15
ESCO2	-2.24	0.12
ZNF292	-2.23	0.12
HNRNPU	-2.21	0.12
GPBP1	-2.20	0.16
C12orf43	-2.20	0.12
YPEL5	-2.19	0.12
ACBD3	-2.19	0.22
NPIPA7	-2.17	0.12
QRICH1	-2.17	0.23
GAK	-2.16	0.12
NPIPA8	-2.16	0.12
ROMO1	3.45	<0.01
TADA1	3.48	<0.01
DHX29	3.49	<0.01
MBTPS2	3.51	<0.01
TAF5L	3.54	<0.01
MED13	3.66	<0.01
ALDH18A1	3.66	<0.01
PFN1	3.68	<0.01
ARHGAP11B	3.74	<0.01
BRPF1	3.86	<0.01
FBXO11	3.87	<0.01
DDX5	3.89	<0.01
STK11	3.91	<0.01
MAX	3.98	<0.01
TRIM28	4.01	<0.01
SRF	4.02	<0.01
AMBRA1	4.42	<0.01
PRKAR1A	4.77	<0.01
TP53	5.20	<0.01
NSD1	5.68	<0.01
CBX3	5.88	<0.01
SETDB1	5.91	<0.01
ID3	5.92	<0.01
KIF2C	5.95	<0.01
TMEM161B	6.03	<0.01
ATP1A1	6.19	<0.01
ATF7IP	6.25	<0.01
NDRG3	6.65	<0.01
ATAT1	6.67	<0.01
KIF18B	7.08	<0.01

Screen	Correlation	Plot
UMK57 1μM R01 exp59	0.14	View
Vinblastine 0.2μM R03 exp108	0.051	View
BML-284 0.09μM R08 exp460	0.172	View
Mdivi-1 15μM R05 exp217	0.133	View
5-Fluorouracil 20μM R00 exp2	0.106	View
Actinomycin-D 0.001μM R00 exp3	0.105	View
3-Bromopyruvate 7μM R04 exp175	0.096	View
Rotenone 20μM R00 exp34	0.091	View
Doxorubicin 0.02μM R08 exp478	0.09	View
Mitomycin-C 0.06μM R08 exp503	0.09	View
CI-1040 9.5μM R08 exp472	0.085	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.084	View
Bleomycin 5μM R08 exp459	0.08	View
Aphidicolin 0.4μM R08 exp440	0.079	View
Deferoxamine 11μM R07 exp350	0.077	View
AICAR 240μM R05 exp211	0.077	View
Atovaquone 15μM R08 exp451	0.076	View
RO-3307 4.7μM R02 exp80	0.074	View
Quercetin 20μM R08 exp517	0.071	View
Pimelic-diphenylamide-106 5μM R00 exp28	0.07	View
Etoposide 0.3μM R05 exp199	0.068	View
Demecolcine 0.03μM R05 exp228	0.068	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.067	View
BVD-523 15μM R02 exp67	0.066	View
PU-H71 1μM R08 exp515	0.066	View
LLY-283 2.6μM R06 exp290	0.064	View
Colchicine 0.009μM R05 exp215	0.063	View
MS023 7μM R03 exp135	0.062	View
Taxol 0.004μM R03 exp103	0.062	View
JQ1 0.8μM R08 exp435	0.061	View
42°C R08 exp539	0.061	View
Ammonium tetrathiomolybdate 10μM R08 exp448	0.06	View
Benzoate 20000μM R08 exp456	0.059	View
SNS-032 15μM R08 exp443	0.057	View
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	0.055	View
LY2090314 0.003μM R08 exp499	0.054	View
THZ1 0.06μM R08 exp531	0.053	View
Artemisinin 50μM R08 exp450	0.053	View
BI-2536 0.02μM R03 exp96	0.052	View
Thimerosal 0.85μM R08 exp529	0.052	View
GSK461364A 0.1μM R03 exp126	0.052	View
MLN-4924 2μM R00 exp22	0.051	View

GO Term	Fold Change	Genes
positive regulation of DNA methylation-dependent heterochromatin formation	165.79	ATF7IP,SETDB1,TRIM28
positive regulation of chromatin organization	127.53	ATF7IP,SETDB1,TRIM28
regulation of DNA methylation-dependent heterochromatin formation	97.52	ATF7IP,SETDB1,TRIM28
regulation of heterochromatin formation	72.08	ATF7IP,SETDB1,TRIM28
regulation of heterochromatin organization	72.08	ATF7IP,SETDB1,TRIM28
promoter-specific chromatin binding	34.01	SETDB1,TP53,TRIM28,DDX5
regulation of transcription initiation by RNA polymerase II	31.13	ATF7IP,TP53,SRF,MED13
regulation of DNA-templated transcription initiation	27.98	ATF7IP,TP53,SRF,MED13
positive regulation of cellular component biogenesis	8.95	ATAT1,ATF7IP,SETDB1,TP53,AMBRA1,SRF,TRIM28,PFN1
DNA-binding transcription factor binding	8.23	ID3,NSD1,TP53,SRF,MAX,DDX5,MED13
transcription factor binding	7.51	ID3,CBX3,NSD1,TP53,SRF,MAX,DDX5,MED13
transferase complex	6.01	PRKAR1A,AMBRA1,MAX,STK11,FBXO11,BRPF1,MED13,TAF5L,TADA1

Table of Contents

UM131593 0.2μM R03 exp106

Mechanism of Action

Technical Notes

Protein References

Protein Supplier

Protein Characterization

Dose Response Curve

Screen Summary

Screen Results