Table of Contents

I-BRD9 4μM R07 exp365

Mechanism of Action

Inhibits BRD9 subunit of SWI/SNF complex

Technical Notes

Protein References

  • PubChem Name: N'-(1,1-Dioxothian-4-yl)-5-ethyl-4-oxo-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide
  • Synonyms: N/A
  • CAS #: 1714146-59-4
  • PubChem CID: 91668541
  • IUPAC: N'-(1,1-dioxothian-4-yl)-5-ethyl-4-oxo-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide
  • INCHI Name: InChI=1S/C22H22F3N3O3S2/c1-2-28-12-17(13-4-3-5-14(10-13)22(23,24)25)19-16(21(28)29)11-18(32-19)20(26)27-15-6-8-33(30,31)9-7-15/h3-5,10-12,15H,2,6-9H2,1H3,(H2,26,27)
  • INCHI Key: WRUWGLUCNBMGPS-UHFFFAOYSA-N
  • Molecular Weight: 497.6
  • Canonical SMILES: CCN1C=C(C2=C(C1=O)C=C(S2)C(=NC3CCS(=O)(=O)CC3)N)C4=CC(=CC=C4)C(F)(F)F
  • Isomeric SMILES: N/A
  • Molecular Formula: C22H22F3N3O3S2

Protein Supplier

  • Supplier Name: Tocris Bioscience
  • Catalog #: 5591
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H22F3N3O3S2 498.11274; found 498.11359

Dose Response Curve

  • Platform ID: I-BRD9
  • Min: -3.1583; Max: 99.2289





IC Concentration (µM)
IC10 N/A
IC20 2.1168
IC30 3.0470
IC40 4.1521
IC50 5.5496
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
12/88ScoresViewViewViewViewView