Table of Contents

Thalidomide 20μM R07 exp406

Mechanism of Action

IMiD that targets neo-substrates IKZF1/3 for ubiquitination by CUL4A-DDB1-cereblon complex

Technical Notes

Protein References

  • PubChem Name: Thalidomide
  • Synonyms: N/A
  • CAS #: 50-35-1
  • PubChem CID: 5426
  • IUPAC: 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • INCHI Name: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
  • INCHI Key: UEJJHQNACJXSKW-UHFFFAOYSA-N
  • Molecular Weight: 258.23
  • Canonical SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
  • Isomeric SMILES: N/A
  • Molecular Formula: C13H10N2O4

Protein Supplier

  • Supplier Name: Cayman Chemical
  • Catalog #: 14610
  • Lot #: 0485409-6

Protein Characterization

  • LCMS: Tr 1.04 min, m/z 259+ [M+H]+

Dose Response Curve

  • Platform ID: rac-Thalidomide
  • Min: -5.7941; Max: 9.9969





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/0ScoresViewViewViewViewView