Table of Contents

Bisphenol S 100μM R08 exp458

Bisphenol S 100μM R08 exp458

Mechanism of Action

BPA analog and substitute in BPA-free plastics, endocrine disrupter

Class / Subclass 1: Environmental Stresses / Industrial Chemical

Technical Notes

Protein References

PubChem Name: 4,4'-Sulfonyldiphenol
Synonyms: N/A
CAS #: 80-09-1
PubChem CID: 6626
IUPAC: 4-(4-hydroxyphenyl)sulfonylphenol
INCHI Name: InChI=1S/C12H10O4S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8,13-14H
INCHI Key: VPWNQTHUCYMVMZ-UHFFFAOYSA-N
Molecular Weight: 250.27
Canonical SMILES: C1=CC(=CC=C1O)S(=O)(=O)C2=CC=C(C=C2)O
Isomeric SMILES: N/A
Molecular Formula: C12H10O4S

Protein Supplier

Supplier Name: Ark Pharm Inc.
Catalog #: AK112768
Lot #: WG0022663-160824001

Protein Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C12H10O4S 251.03726; found 251.03703

Dose Response Curve

Platform ID: Bisphenol_S
Min: -9.1579; Max: 15.4679

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 08
Dose: 100µM
Days of incubation: 8
Doublings: 4.6
Numbers of reads: 14220037

Screen Results

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/2	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
MCM9	-2.69	0.15
SWI5	-2.51	0.15
ALG3	-2.40	0.15
FAM50A	-2.39	0.60
MPDU1	-2.38	0.18
ALG9	-2.37	0.15
ALG5	-2.37	0.15
DPM3	-2.36	0.15
PRKAA1	-2.28	0.18
HMBOX1	-2.23	0.18
LEO1	-2.23	0.18
CSK	-2.22	0.18
DPM1	-2.15	0.39
A1CF	-2.13	0.39
BTBD9	-2.13	0.39
TOMM7	-2.10	0.33
BCL2	-2.06	0.38
RAPH1	-2.05	0.38
RBMX2	-2.04	0.43
CNOT11	-2.02	0.53
SLC25A23	-2.00	0.46
PTEN	-1.98	0.41
YES1	-1.97	0.41
UPF3B	-1.97	0.41
GSK3B	-1.95	0.43
TRIAP1	-1.93	0.58
TBCA	-1.93	0.43
RAD51B	-1.92	0.53
FOXK1	-1.92	0.43
ZNF232	-1.92	0.43
ZNF727	2.03	0.29
DDX18	2.03	0.47
ARL6IP4	2.03	0.47
STAC2	2.05	0.27
CCL5	2.06	0.27
ATP6AP1	2.09	0.69
RPL8	2.10	0.76
KIAA1429	2.10	0.51
ZNF148	2.11	0.24
ESM1	2.12	0.24
UQCC2	2.14	0.29
CCNL1	2.15	0.24
PDS5A	2.16	0.24
TIPRL	2.20	0.23
MS4A13	2.24	0.71
CXorf56	2.25	0.24
CD19	2.26	0.24
METTL14	2.27	0.46
JMJD6	2.29	0.15
CITED2	2.30	0.15
SLC35F3	2.36	0.15
GTF2E2	2.36	0.25
GAGE2A	2.36	0.61
MFAP1	2.43	0.15
RPL36	2.55	0.24
ODC1	2.63	0.06
PPWD1	2.70	0.15
TMEM187	2.96	0.03
EXOSC7	3.02	0.11
RBM26	3.07	0.03

GO Term	Fold Change	Genes
dolichol-linked oligosaccharide biosynthetic process	120.28	ALG3,MPDU1,ALG9,DPM1
oligosaccharide-lipid intermediate biosynthetic process	114.27	ALG3,MPDU1,ALG9,DPM1
dolichol metabolic process	108.83	ALG3,MPDU1,ALG9,DPM3
polyprenol metabolic process	99.36	MPDU1,ALG9,DPM3,DPM1
protein N-linked glycosylation	41.40	ALG3,MPDU1,ALG9,ALG5,DPM1
isoprenoid metabolic process	22.32	ALG3,MPDU1,ALG9,DPM3,DPM1
protein glycosylation	18.53	ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1
macromolecule glycosylation	18.53	ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1
glycosylation	16.48	ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1
glycoprotein biosynthetic process	13.71	ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1
glycoprotein metabolic process	10.92	ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1
alcohol metabolic process	10.81	ALG3,MPDU1,ALG9,DPM3,PRKAA1,DPM1
organic hydroxy compound metabolic process	9.66	ALG3,MPDU1,ALG9,DPM3,PRKAA1,DPM1,BTBD9,BCL2

GO Term	Fold Change	Genes
RNA splicing	10.71	PPWD1,MFAP1,JMJD6,METTL14,VIRMA,ARL6IP4,USP39
mRNA processing	10.20	RBM26,PPWD1,MFAP1,JMJD6,METTL14,VIRMA,ARL6IP4,USP39
mRNA metabolic process	8.44	RBM26,EXOSC7,PPWD1,MFAP1,JMJD6,METTL14,VIRMA,ARL6IP4,USP39
RNA processing	6.65	RBM26,EXOSC7,PPWD1,MFAP1,JMJD6,METTL14,VIRMA,ARL6IP4,DDX18,USP39