LY2090314 0.003μM R08 exp499

Inhibits glycogen synthase kinase-3 (GSK-3), activates Wnt signalling

PubChem Name: 3-[6-Fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione
Synonyms: N/A
CAS #: 603288-22-8
PubChem CID: 10029385
IUPAC: 3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione
INCHI Name: InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)
INCHI Key: HRJWTAWVFDCTGO-UHFFFAOYSA-N
Molecular Weight: 512.5
Canonical SMILES: C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7
Isomeric SMILES: N/A
Molecular Formula: C28H25FN6O3

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
56/94	Scores	View	View	View	View	View

Screen	Correlation	Plot
LY2090314 0.003μM R08 exp500 no dilution day6	0.448	View
MLN-4924 0.2μM R00 exp21	0.102	View
Quercetin 20μM R08 exp517	0.065	View
Milciclib 2μM R08 exp502	0.065	View
TRAIL 5ng/ml R00 exp35	0.06	View
Radicicol 0.16μM R05 exp242	0.054	View
UM131593 0.2μM R03 exp106	0.054	View
RO-3307 4.7μM R02 exp80	0.051	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.051	View
JQ1 0.8μM R08 exp435	0.059	View
Hippuristanol 0.12μM R08 exp489 no dilution day6	0.059	View
Amiloride 100μM R08 exp447	0.059	View
3-Bromopyruvate 7μM R04 exp175	0.058	View
BVD-523 15μM R02 exp67	0.058	View
Ethanol 0.01 R05 exp234	0.056	View
CB-5083 0.4μM R08 exp468	0.055	View
Aphidicolin 0.4μM R08 exp440	0.055	View
Actinomycin-D 0.001μM R00 exp3	0.055	View
I-BRD9 4μM R07 exp365	0.054	View
AICAR 240μM R05 exp211	0.052	View
Artemisinin 50μM R08 exp450	0.051	View

GO Term	Fold Change	Genes
GATOR1 complex	637.27	NPRL3,NPRL2
Seh1-associated complex	273.12	NPRL3,DEPDC5,NPRL2
negative regulation of TORC1 signaling	108.80	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,PRKAA1,STK11
negative regulation of TOR signaling	67.59	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,PRKAA1,STK11
cellular response to amino acid starvation	66.38	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2
response to amino acid starvation	62.48	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2
regulation of TORC1 signaling	59.28	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,OTUB1,PRKAA1,STK11
cellular response to glucose starvation	39.83	ITFG2,SZT2,PRKAA1
regulation of TOR signaling	33.04	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,PRKAA1,STK11
positive regulation of autophagy	26.19	GSK3B,NPRL3,DEPDC5,NPRL2,PRKAA1,STK11
cellular response to starvation	22.36	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,PRKAA1
response to starvation	18.21	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,PRKAA1
cellular response to nutrient levels	16.41	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,PRKAA1
cellular response to extracellular stimulus	14.59	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,PRKAA1
negative regulation of intracellular signal transduction	12.45	GSK3B,NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,IVNS1ABP,PRKAA1,BCL6,STK11
positive regulation of cellular catabolic process	12.22	GSK3B,NPRL3,DEPDC5,NPRL2,PRKAA1,STK11
cellular response to external stimulus	11.69	NPRL3,DEPDC5,ITFG2,SZT2,NPRL2,PRKAA1
regulation of autophagy	10.99	GSK3B,NPRL3,DEPDC5,NPRL2,PRKAA1,STK11
regulation of cellular catabolic process	6.93	GSK3B,NPRL3,DEPDC5,NPRL2,PRKAA1,ELAVL1,STK11

GO Term	Fold Change	Genes
positive regulation of pentose-phosphate shunt	552.30	MLST8,RPTOR
regulation of pentose-phosphate shunt	276.15	MLST8,RPTOR,MTOR
regulation of NADP metabolic process	236.70	MLST8,RPTOR,MTOR
TOR complex	165.69	MLST8,RPTOR,MTOR
TORC1 signaling	150.63	MLST8,RPTOR,MTOR
beta-catenin-TCF complex	138.08	LEF1,CTNNB1,BCL9
calcineurin-NFAT signaling cascade	118.35	MTOR,PPP3R1,PPP3CA
positive regulation of purine nucleotide metabolic process	97.46	MLST8,RPTOR,MTOR
positive regulation of myeloid leukocyte differentiation	38.76	LEF1,RB1,RPTOR,PPP3CA
positive regulation of myeloid cell differentiation	28.77	LEF1,RB1,RPTOR,BRD1,PPP3CA
regulation of myeloid leukocyte differentiation	28.08	LEF1,CTNNB1,RB1,RPTOR,MTOR,PPP3CA
regulation of myeloid cell differentiation	20.56	LEF1,CTNNB1,RB1,RPTOR,MTOR,BRD1,PPP3CA
regulation of leukocyte differentiation	12.35	LEF1,CTNNB1,ARID1A,RB1,RPTOR,MTOR,PPP3CA
regulation of hemopoiesis	11.36	LEF1,CTNNB1,ARID1A,RB1,RPTOR,MTOR,BRD1,PPP3CA
positive regulation of cell development	10.16	LEF1,CTNNB1,ARID1A,RB1,RPTOR,MTOR,HDAC1,PPP3CA
DNA-binding transcription factor binding	9.42	LEF1,CTNNB1,JUP,ID3,NSD1,ARID1A,RB1,HDAC1
transcription factor binding	9.39	LEF1,CTNNB1,JUP,ID3,NSD1,ARID1A,RB1,RPTOR,MTOR,HDAC1
transcription coregulator activity	9.07	CTNNB1,JUP,NSD1,ARID1A,RB1,DYRK1A,BCL9,HDAC1
muscle structure development	8.87	CTNNB1,ID3,MBNL1,FOXK1,RB1,BCL9,MTOR,PPP3CA