CCT251545 20μM R07 exp326

Mechanism of Action

Inhibits CDK8 and CDK19 mediator-associated kinases

  • Class / Subclass 1: Gene Regulation / Transcription Inhibitor
  • Class / Subclass 2: Signal Transduction / Kinase Inhibitor

Technical Notes

Compound References

  • PubChem Name: 8-{3-Chloro-5-[4-(1-Methyl-1h-Pyrazol-4-Yl)phenyl]pyridin-4-Yl}-2,8-Diazaspiro[4.5]decan-1-One
  • Synonyms: N/A
  • CAS #: 1661839-45-7
  • PubChem CID: 77050682
  • IUPAC: 8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
  • INCHI Name: InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)
  • INCHI Key: LBFYQISQYCGDDW-UHFFFAOYSA-N
  • Molecular Weight: 421.9
  • Canonical SMILES: CN1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC(=C3N4CCC5(CCNC5=O)CC4)Cl
  • Isomeric SMILES: N/A
  • Molecular Formula: C23H24ClN5O

Compound Supplier

  • Supplier Name: Cayman Chemical
  • Catalog #: 18761
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H24ClN5O 422.17421; found 422.1743

Dose Response Curve

  • Platform ID: CCT251545
  • Min: -8.9474; Max: 38.9173





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 20µM
  • Days of incubation: 8
  • Doublings: 4.0
  • Numbers of reads: 22004748

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
7/1ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1