Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471
Mechanism of Action
Major membrane lipid, precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D
- Class / Subclass 1: Metabolism / Metabolite
Technical Notes
Compound References
- PubChem Name: Cholesterol
- Synonyms: N/A
- CAS #: 57-88-5
- PubChem CID: 5997
- IUPAC: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
- INCHI Name: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
- INCHI Key: HVYWMOMLDIMFJA-DPAQBDIFSA-N
- Molecular Weight: 386.7
- Canonical SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
- Isomeric SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
- Molecular Formula: C27H46O
Compound Supplier
- Supplier Name: Combi-Blocks
- Catalog #: QE-3931
- Lot #: B15201
Compound Characterization
- HPLC-ELS: Tr 2.69 min.
Dose Response Curve
- Platform ID: Cholesterol
- Min: 11.1840; Max: 96.6964
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.0001 |
| IC30 | 0.0002 |
| IC40 | 0.0004 |
| IC50 | 0.0007 |
| IC60 | 0.0011 |
| IC70 | 0.0018 |
| IC80 | 0.0036 |
| IC90 | 0.0096 |
Screen Summary
- Round: 08
- Dose: 3-100nM
- Days of incubation: 8
- Doublings: 7.2
- Numbers of reads: 15819582
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471 vs L-BMAA 500 to 750μM on day4 R04 exp185
