TIC10 10μM R08 exp532

Inhibits mitochondrial CLPP protease, a.k.a. ONC201, parent of ONC212, possible agonist of GPR132

PubChem Name: 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5(4H)-one
Synonyms: ONC-201
CAS #: 1616632-77-9
PubChem CID: 73777259
IUPAC: 11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one
INCHI Name: InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3
INCHI Key: VLULRUCCHYVXOH-UHFFFAOYSA-N
Molecular Weight: 386.5
Canonical SMILES: CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5
Isomeric SMILES: N/A
Molecular Formula: C24H26N4O

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/12	Scores	View	View	View	View	View

Screen	Correlation	Plot
Tanespimycin 14μM R08 exp527	0.112	View
Thimerosal 0.85μM R08 exp529	0.085	View
Vinblastine 0.2μM R03 exp108	0.051	View
ONC212 0.15μM R08 exp513	0.145	View
GSK-J4 1.5μM R08 exp441	0.111	View
Mitomycin-C 0.06μM R08 exp503	0.11	View
CI-1040 9.5μM R08 exp472	0.089	View
PU-H71 1μM R08 exp515	0.083	View
Hydroxyurea 100μM R07 exp329	0.078	View
JQ1 0.8μM R08 exp435	0.076	View
CR131-b 0.005μM R08 exp474	0.074	View
Atovaquone 15μM R08 exp451	0.074	View
Ammonium tetrathiomolybdate 10μM R08 exp448	0.07	View
Aphidicolin 0.4μM R08 exp440	0.066	View
Rotenone 0.07μM R08 exp431	0.066	View
THZ1 0.06μM R08 exp531	0.06	View
Deferoxamine 11μM R07 exp350	0.06	View
Milciclib 2μM R08 exp502	0.06	View
Hinokiflavone 12μM R08 exp487	0.06	View
Amiloride 100μM R08 exp447	0.055	View
Doxorubicin 0.02μM R08 exp478	0.051	View
CoCl2 18μM R07 exp346	0.051	View

GO Term	Fold Change	Genes
mitochondrial tRNA 5-end processing	552.30	PRORP,HSD17B10
mitochondrial RNA 5-end processing	368.20	PRORP,HSD17B10
mitochondrial RNA processing	82.85	PRORP,HSD17B10,FASTKD5
phosphotransferase activity, for other substituted phosphate groups	78.90	CEPT1,DPAGT1,PTDSS1
mitochondrial RNA metabolic process	51.38	DARS2,HSD17B10,FASTKD5,SARS2
cytochrome complex assembly	48.73	COX16,BCS1L,HCCS
mitochondrial gene expression	27.81	PRORP,DARS2,GATC,HSD17B10,FASTKD5,SARS2,MRPS33
catalytic activity, acting on a tRNA	22.09	PRORP,TRMT10A,DARS2,GATC,SARS2
tRNA metabolic process	17.82	PRORP,TRMT10A,DARS2,GATC,HSD17B10,SARS2
mitochondrial protein-containing complex	12.09	PRORP,HSD17B10,BCS1L,COX7B,ATP5PF,MRPS33
mitochondrial matrix	9.32	MIPEP,CLPP,PRORP,DARS2,HSD17B10,FASTKD5,SARS2,MRPS33