Prochlorperazine 5.2μM R02 exp77

Mechanism of Action

Antagonist of DRD2 receptors, used to treat nausea, schizophrenia, migraines, anxiety

  • Class / Subclass 1: Signal Transduction / GPCR Antagonist

Technical Notes

Compound References

  • PubChem Name: Prochlorperazine maleate
  • Synonyms: N/A
  • CAS #: 84-02-6
  • PubChem CID: 5281032
  • IUPAC: (Z)-but-2-enedioic acid;2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
  • INCHI Name: InChI=1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
  • INCHI Key: DSKIOWHQLUWFLG-SPIKMXEPSA-N
  • Molecular Weight: 606.1
  • Canonical SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
  • Isomeric SMILES: CN1CCN(CC1)CCCN2C3=C(SC4=CC=CC=C24)C=CC(=C3)Cl.C(=C\\C(=O)O)\\C(=O)O.C(=C\\C(=O)O)\\C(=O)O
  • Molecular Formula: C28H32ClN3O8S

Compound Supplier

  • Supplier Name: Tocris Bioscience
  • Catalog #: 3287
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H24ClN3S 374.14522; found 374.14674

Dose Response Curve

  • Platform ID: Prochlorperazine
  • Min: -0.6151; Max: 98.0607





IC Concentration (µM)
IC10 N/A
IC20 4.6246
IC30 5.1702
IC40 5.6652
IC50 6.1610
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 02
  • Dose: 5.2µM
  • Days of incubation: 8
  • Doublings: 6.8
  • Numbers of reads: 9745730

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1