ALAS1
Gene Information
- Official Symbol: ALAS1
- Official Name: 5'-aminolevulinate synthase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 211
- UniProt: P13196
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Preseq ALAS |
| Aminotran 1 2 |
GO Terms
| 5-aminolevulinate synthase activity |
| protoporphyrinogen IX biosynthetic process |
| protoporphyrinogen IX metabolic process |
| heme biosynthetic process |
| porphyrin-containing compound biosynthetic process |
| tetrapyrrole biosynthetic process |
| heme metabolic process |
| porphyrin-containing compound metabolic process |
| pigment biosynthetic process |
| pyridoxal phosphate binding |
| tetrapyrrole metabolic process |
| pigment metabolic process |
| cofactor biosynthetic process |
| mitochondrial matrix |
| regulation of lipid metabolic process |
| cofactor metabolic process |
| mitochondrion organization |
| identical protein binding |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| mitochondrion |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| FECH | 0.743 |
| HMBS | 0.612 |
| ALAD | 0.519 |
| RBFA | 0.477 |
| NARS2 | 0.47 |
| CPOX | 0.459 |
| BAK1 | 0.456 |
| NDUFAF7 | 0.455 |
| YARS2 | 0.447 |
| MRPL21 | 0.444 |
| MRPS21 | 0.443 |
| BCS1L | 0.442 |
| C17orf89 | 0.44 |
| TEFM | 0.44 |
| GLRX5 | 0.439 |
| NDUFA11 | 0.439 |
| NDUFB11 | 0.435 |
| TARS2 | 0.434 |
| MRPS6 | 0.431 |
| COQ3 | 0.431 |
| SELRC1 | 0.428 |
| MARCH5 | 0.428 |
| GFM1 | 0.427 |
| NDUFA2 | 0.426 |
| MRPS24 | 0.423 |
| MRPL47 | 0.42 |
| RNASEH1 | 0.418 |
| TUFM | 0.418 |
| TIMM17A | 0.417 |
| SARS2 | 0.416 |
| WBSCR16 | 0.412 |
| GTPBP10 | 0.409 |
| HCCS | 0.407 |
| RPUSD4 | 0.407 |
| LRPPRC | 0.407 |
| MRPS16 | 0.401 |
| NDUFC2 | 0.401 |
| MTG1 | 0.4 |
| NDUFA3 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 977
- Expression level (log2 read counts): 5.3
Expression Distribution
ALAS1 Expression in NALM6 Cells: 5.3
