C14orf80 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: TEDC1
Official Name: tubulin epsilon and delta complex 1
Aliases and Previous Symbols: N/A
Entrez ID: 283643
UniProt: Q86SX3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F. {ECO:0000269|PubMed:28796488}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TGF-beta1 44ng/ml R08 exp528	-2.24
BI-6727 0.0125μM R03 exp97	-1.9
Thalidomide 20μM R07 exp406	-1.8
BI-2536 0.0042μM R03 exp95	-1.79
GSK461364A 0.005μM R03 exp125	-1.77
SGC2043 10μM R03 exp152	-1.71
UMK57 0.6μM R03 exp107	-1.71
CI-1040 9.5μM R08 exp472	1.88
Centrinone 0.5μM R07 exp343	1.91
HMS-I1 10μM R06 exp256	1.94
Cytochalasin-B 5μM R07 exp349	5.15
Latrunculin-B 10μM R07 exp374	5.28
Tozasertib 0.1μM R07 exp414	6.42

Gene	Correlation
C16orf59	0.799
TUBD1	0.788
TUBE1	0.718
CEP120	0.679
PIDD	0.637
ODF2	0.633
CEP44	0.622
C2CD3	0.62
PIBF1	0.599
CASP2	0.598
CRADD	0.594
OFD1	0.559
RTTN	0.559
KIAA0753	0.55
BUB3	0.541
CCDC41	0.541
ANKRD26	0.535
SCLT1	0.533
NIN	0.508
SRP14	0.498
URM1	0.483
GEMIN8	0.478
THG1L	0.478
CEP76	0.474
N6AMT1	0.474
CEP128	0.464
CENPA	0.464
ELP3	0.463
FOPNL	0.462
PPP2R3C	0.455
CEP152	0.452
FGFR1OP	0.451
WDR1	0.451
TKT	0.451
DNAJB6	0.44
FNTB	0.44
TSEN54	0.439
SRP9	0.436
ATXN10	0.432
FBXW7	0.431
HYLS1	0.43
KDM8	0.429
RPP21	0.429
NSMCE1	0.429
KIAA0586	0.427
HSPA4	0.427
CEP78	0.424
DDX42	0.424
DPAGT1	0.417
NHLRC2	0.41
GEMIN6	0.408
PFN1	0.406
UAP1	0.404
ALG1	0.403
TBCA	0.403
ATIC	0.401
IPP	0.4
RBBP4	0.4

Global Fraction of Cell Lines Where Essential: 53/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	1/28
bone	2/26
breast	0/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	4/21
liver	3/20
lung	6/75
lymphocyte	0/16
ovary	1/26
pancreas	2/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	2/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 777
Expression level (log2 read counts): 4.8

Expression Distribution

Last modified: 2026/01/07 22:36
by 127.0.0.1