DLGAP5

Gene Information

Official Symbol: DLGAP5
Official Name: DLG associated protein 5
Aliases and Previous Symbols: N/A
Entrez ID: 9787
UniProt: Q15398
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-4.35
Vinblastine 0.002μM R01 exp60	-3.95
UMK57 1μM R01 exp59	-3.66
Demecolcine 0.03μM R05 exp228	-3.39
BML-284 0.09μM R08 exp460	-3.37
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-3.24
Vincristine 0.0005μM R04 exp190	-3.23
Sulforaphane 9μM R08 exp526 no dilution day6	-3.16
S-trityl-L-cysteine 0.5μM R05 exp243	-3.1
Taxol 0.004μM R03 exp103	-3.1
BI-6727 0.0125μM R03 exp97	-2.98
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.95
Centrinone 0.5μM R07 exp343	-2.87
Cabazitaxel 0.001μM R05 exp223	-2.77
Taxol 0.002μM R01 exp54	-2.71
Docetaxel 0.002μM R01 exp45	-2.65
Vinorelbine 0.001μM R05 exp249	-2.56
UM131593 0.2μM R03 exp106	-2.49
Quercetin 20μM R08 exp517	-2.46
Chlorpromazine 10μM R07 exp344	-2.3
Sulforaphane 9μM R08 exp525	-2.2
UMK57 0.6μM R03 exp107	-2.15
2-Methoxyestradiol 0.55μM R07 exp310	-2.13
Thimerosal 0.85μM R08 exp529	-2.13
GSK461364A 0.005μM R03 exp125	-2.09
Mdivi-1 15μM R05 exp217	-2.08
HMS-I1 1μM R01 exp46	-1.92
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.76
Epothilone-B 0.0015μM R05 exp231	-1.76
Milciclib 2μM R08 exp502	-1.74

Gene	Correlation
TACC3	0.75
KIF15	0.625
ASPM	0.586
GAK	0.585
GTSE1	0.58
GSG2	0.525
KLF16	0.5
CDCA2	0.489
SEPHS1	0.468
MAPRE1	0.461
ESCO2	0.429
CALM2	0.427
LRRC8A	0.403

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6935
Expression level (log2 read counts): 6.87

Expression Distribution

mitotic chromosome movement towards spindle pole
chromosome movement towards spindle pole
positive regulation of mitotic sister chromatid separation
positive regulation of mitotic metaphase/anaphase transition
positive regulation of metaphase/anaphase transition of cell cycle
positive regulation of chromosome separation
spindle pole centrosome
positive regulation of mitotic sister chromatid segregation
positive regulation of transcription of Notch receptor target
positive regulation of chromosome segregation
phosphoprotein phosphatase activity
regulation of mitotic metaphase/anaphase transition
positive regulation of mitotic nuclear division
regulation of metaphase/anaphase transition of cell cycle
regulation of mitotic sister chromatid separation
regulation of chromosome separation
positive regulation of nuclear division
regulation of mitotic sister chromatid segregation
establishment of chromosome localization
chromosome localization
positive regulation of mitotic cell cycle phase transition
regulation of sister chromatid segregation
positive regulation of cell cycle phase transition
regulation of chromosome segregation
mitotic sister chromatid segregation
Notch signaling pathway
sister chromatid segregation
mitotic nuclear division
positive regulation of mitotic cell cycle
microtubule organizing center
regulation of mitotic nuclear division
positive regulation of chromosome organization
regulation of nuclear division
protein dephosphorylation
nuclear chromosome segregation
microtubule-based movement
chromosome segregation
nuclear division
positive regulation of cell cycle process
dephosphorylation