HEXIM1

Gene Information

Official Symbol: HEXIM1
Official Name: HEXIM P-TEFb complex subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 10614
UniProt: O94992
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
3-Bromopyruvate 7μM R04 exp175	-3.27
CoCl2 18μM R07 exp346	-2.86
Actinomycin-D 0.001μM R00 exp3	-2.85
BML-284 0.09μM R08 exp460	-2.58
Artemisinin 50μM R08 exp450	-2.52
Dynasore 10μM R04 exp180	-2.52
UM0125461 0.74μM R02 exp84	-2.51
UM131593 0.2μM R03 exp106	-2.51
Pimelic-diphenylamide-106 5μM R00 exp28	-2.48
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.39
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.34
Tubacin 1.6μM R07 exp416	-2.34
GSK591 2.6μM R03 exp128	-2.31
Trimetrexate 0.03μM R08 exp535	-2.31
MLN-4924 2μM R00 exp22	-2.28
Golgicide-A 4μM R03 exp122	-2.21
Dinaciclib 0.007μM R07 exp355	-2.17
LLY-283 2.6μM R06 exp290	-2.14
Methotrexate 0.01μM R08 exp501	-2.13
INK128 0.2μM R02 exp70	-1.97
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.95
Clomiphene 4.4μM R02 exp68	-1.95
S-trityl-L-cysteine 0.5μM R05 exp243	-1.92
Colchicine 0.009μM R05 exp215	-1.87
HMS-I2 10μM R06 exp288	-1.86
Quercetin 20μM R08 exp517	-1.83
TIC10 10μM R08 exp532	-1.81
Selumetinib 20μM R02 exp81	-1.78
Genistein 15μM R07 exp360	-1.75
AICAR 240μM R05 exp211	-1.74
PU-H71 1μM R08 exp515	-1.7
Betulinic acid 10 to 15μM on day4 R05 exp222	1.74
Sulforaphane 9μM R08 exp526 no dilution day6	1.77
proTAME 5μM R04 exp187	1.81
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.84
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.88
GSK626616 14μM R08 exp485	1.92
B02 10μM R08 exp453	2
RO-3307 4.7μM R02 exp80	2.14
Sulforaphane 9μM R08 exp525	2.18
BI-6727 0.0125μM R03 exp97	2.54
Benzoate 10000μM R08 exp455	2.65
BI-2536 0.0042μM R03 exp95	2.65
Lead acetate 2000μM R08 exp497	2.76
THZ531 0.225μM R08 exp444	2.93
Tozasertib 0.1μM R07 exp414	3.01
Ethanol 0.01 R05 exp234	3.77
Lead acetate 2000μM R08 exp498 no dilution day6	3.8

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17768
Expression level (log2 read counts): 4.93

Expression Distribution

Gene	Correlation
LARP7	0.633
RBM26	0.481
PRIM1	0.445
ING1	0.442
MEPCE	0.437
SZT2	0.426
BRMS1	0.422
NPRL3	0.402

snRNA binding
7SK snRNA binding
cyclin-dependent protein serine/threonine kinase inhibitor activity
positive regulation of signal transduction by p53 class mediator
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cyclin-dependent protein kinase activity
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
negative regulation of protein serine/threonine kinase activity
regulation of signal transduction by p53 class mediator
negative regulation of protein kinase activity
negative regulation of kinase activity
activation of innate immune response
negative regulation of transferase activity
positive regulation of innate immune response
positive regulation of response to biotic stimulus
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of protein serine/threonine kinase activity
regulation of response to biotic stimulus
heart development
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of cell cycle
negative regulation of protein modification process
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
innate immune response
regulation of multi-organism process
negative regulation of catalytic activity
regulation of protein kinase activity
negative regulation of transcription by RNA polymerase II
positive regulation of immune response
circulatory system development
regulation of kinase activity
defense response to other organism