PRRC2C

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.52
Fluvastatin 2.2μM R06 exp282	-2.48
MSC2530818 10μM R07 exp379	-2.39
Ribavirin 10 to 15μM on day4 R04 exp160	-2.35
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.98
Vemurafenib 6.6μM R08 exp434	-1.79
HMS-I2 1μM R06 exp286	-1.77
Senexin-A 25μM R07 exp400	-1.77
Bafilomycin-A1 0.009μM R08 exp454	-1.75
Rapamycin 1μM R00 exp29	-1.72
Tenofovir 10μM R07 exp405	-1.72
S-trityl-L-cysteine 0.5μM R05 exp243	-1.71
Rapamycin 0.001μM R08 exp429	-1.7
Citral 50μM R06 exp274	1.71
LB-100 4.1μM R02 exp72	1.74
Centrinone 0.5μM R07 exp343	1.75
GSK626616 14μM R08 exp485	1.76
UM0011500 10μM R05 exp246	1.76
THZ1 0.06μM R08 exp531	1.78
Bleomycin 5μM R08 exp459	1.8
VER-155008 3.9μM R06 exp301	1.81
UM0129480 7μM R02 exp85	1.86
Hydroxyurea 100μM R07 exp329	1.91
2-Deoxy-D-glucose 800μM R05 exp214	1.94
LB-100 2μM R05 exp210	1.98
Cannabidiol 20μM R08 exp466	2.02
Aphidicolin 0.4μM R08 exp440	2.06
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.11
Talazoparib 0.006μM R06 exp299	2.12
Hippuristanol 0.12μM R08 exp488	2.13
Mitomycin-C 0.06μM R08 exp503	2.13
Trimetrexate 0.03μM R08 exp535	2.17
Thimerosal 0.85μM R08 exp529	2.27
Quercetin 20μM R08 exp517	2.37
Palbociclib 1μM R07 exp382	2.41
Diepoxybutane 3μM R07 exp354	2.52
JQ1 0.8μM R08 exp435	2.64
Aminopterin 0.005μM R07 exp335	2.69
Olaparib 4μM R08 exp512	2.78
Lead acetate 2000μM R08 exp498 no dilution day6	3.11
Lead acetate 2000μM R08 exp497	3.75
Citral 75μM R06 exp275	3.87
Ethanol 0.01 R05 exp234	4.11
Bortezomib 0.005μM R00 exp6	5.07

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hematopoietic progenitor cell differentiation
protein C-terminus binding
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
RNA binding
membrane