RBM14-RBM4

Gene Information

Official Symbol: N/A
Official Name: N/A
Aliases and Previous Symbols: N/A
Entrez ID: N/A
UniProt: N/A
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.74
BI-D1870 2μM R04 exp162	-2.51
Etoposide 0.1μM R05 exp198	-2.34
GSK343 3μM R03 exp124	-2.32
Cisplatin 0.35μM R06 exp273	-2.3
L-BMAA 500 to 750μM on day4 R04 exp185	-2.24
Mubritinib 0.2μM R02 exp65	-2.22
LJH685 5μM R02 exp73	-2.18
Rucaparib 6.5μM R08 exp520	-2.11
SGC2096 2.6μM R03 exp153	-2.1
ML-792 0.2μM R08 exp505	-2.05
Hydroxyurea 15μM R06 exp289	-1.98
Nutlin-3A 1.6μM R06 exp294	-1.98
Hypoxia 5%O2 R04 exp191	-1.96
UMK57 0.6μM R03 exp107	-1.92
QNZ 0.01μM R08 exp439	-1.9
Bafilomycin-A1 0.009μM R08 exp454	-1.88
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.87
UMK57 1μM R01 exp59	-1.87
BH1 1μM R04 exp169	-1.86
Nocodazole 0.02μM R00 exp23	-1.84
UNC2400 2μM R03 exp156	-1.83
UM0011500 5μM R05 exp245	-1.82
Epigallocatechin gallate 20μM R05 exp230	-1.78
JQ1 0.01μM R03 exp130	-1.78
GSK591 2.6μM R03 exp128	-1.73
Hydroxyurea 100μM R07 exp329	-1.72
Mubritinib 0.2μM R01 exp48	-1.71
Wiskostatin 3μM R07 exp422	-1.7
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.83
Cytochalasin-B 5μM R07 exp349	1.89
Hippuristanol 0.12μM R08 exp488	2.01
Tozasertib 0.1μM R07 exp414	2.29
Centrinone 0.5μM R07 exp343	2.31
BI-2536 0.02μM R03 exp96	2.32
GSK461364A 0.1μM R03 exp126	2.4
DABN 20μM R00 exp17	2.43
Bortezomib 0.05μM R00 exp7	2.9
DABN racemic mixture R03 exp93	3.74
R-DABN 8μM R03 exp111	3.8
SB743921 0.001μM R05 exp244	4.41
BI-6727 0.04μM R03 exp98	4.76
Nocodazole 0.2μM R02 exp64	5.04
Nocodazole 0.1μM R03 exp94	5.25
HMS-I1 10μM R06 exp256	5.5
Rotenone 2μM R00 exp33	5.72
Nocodazole 0.2μM R00 exp24	5.82
Vinblastine 0.015μM R05 exp208	5.92

Essentiality in NALM6

Essentiality Rank: 289
Expression level (log2 read counts): 4.68

Expression Distribution

zf-CCHC
RRM 1