SMG5

Entrez Summary: N/A
UniProt Summary: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp488	-2.77
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.77
Bortezomib 0.05μM R00 exp7	-2.72
Dinaciclib 0.007μM R07 exp355	-2.49
Aphidicolin 0.4μM R08 exp440	-2.32
DABN racemic mixture R03 exp93	-2.22
Centrinone 0.5μM R07 exp343	-2.1
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2
Benzoate 20000μM R08 exp456	-1.99
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.93
Trientine 500μM R08 exp534	-1.91
BI-6727 0.04μM R03 exp98	-1.88
5-Fluorouracil 20μM R00 exp2	-1.87
Dihydrosphingosine 8μM R08 exp476	-1.86
Milciclib 2μM R08 exp502	-1.81
BI-D1870 3.15μM R02 exp66	-1.75
TNF-alpha 44ng/ml R08 exp533	-1.75
Salinomycin 3.5μM R08 exp521	-1.74
CR131-b 0.005μM R08 exp474	-1.72
Quercetin 20μM R08 exp517	-1.71
Thimerosal 0.85μM R08 exp529	-1.71
Fluvastatin 2.2μM R06 exp282	1.71
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.73
Cerivastatin 0.15μM R05 exp226	1.74
Thalidomide 20μM R07 exp406	1.74
Vincristine 0.0005μM R04 exp190	1.75
SB202190 10μM R03 exp148	1.8
BRD2 inhibitor II 20μM R07 exp341	1.82
BI-6727 0.0125μM R03 exp97	1.84
CCT251545 20μM R07 exp326	1.85
Campthothecin 0.001μM R06 exp270	1.98
Nicotinamide Riboside 100μM R03 exp139	2.1
Rifampicin 1μM R00 exp31	2.11
MLN-4924 0.2μM R00 exp21	2.22
L-BMAA 500 to 750μM on day4 R04 exp185	2.32
RO-3306 3 to 4μM on day4 R04 exp165	2.59

Global Fraction of Cell Lines Where Essential: 407/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	9/28
blood	19/28
bone	16/26
breast	20/33
central nervous system	29/56
cervix	2/4
colorectal	15/17
esophagus	4/13
fibroblast	0/1
gastric	8/16
kidney	9/21
liver	11/20
lung	43/75
lymphocyte	11/16
ovary	17/26
pancreas	13/24
peripheral nervous system	8/16
plasma cell	10/15
prostate	0/1
skin	13/24
soft tissue	7/9
thyroid	0/2
upper aerodigestive	11/22
urinary tract	13/29
uterus	3/5

Expression Distribution

telomerase holoenzyme complex
telomere maintenance via telomerase
telomerase RNA binding
telomeric DNA binding
telomere maintenance via telomere lengthening
protein phosphatase 2A binding
RNA-dependent DNA biosynthetic process
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
regulation of telomere maintenance
telomere maintenance
telomere organization
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
DNA biosynthetic process
histone deacetylase binding
regulation of DNA biosynthetic process
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
protein export from nucleus
mRNA transport
nuclear export
RNA transport
nucleic acid transport
establishment of RNA localization
nuclear-transcribed mRNA catabolic process
regulation of dephosphorylation
RNA localization
mRNA catabolic process
nucleobase-containing compound transport
RNA catabolic process
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
ubiquitin protein ligase binding
anatomical structure homeostasis
regulation of chromosome organization
regulation of DNA metabolic process