UBE2K
Gene Information
- Official Symbol: UBE2K
- Official Name: ubiquitin conjugating enzyme E2 K
- Aliases and Previous Symbols: N/A
- Entrez ID: 3093
- UniProt: P61086
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| UBA |
| UQ con |
GO Terms
| free ubiquitin chain polymerization |
| ubiquitin recycling |
| positive regulation of type I interferon-mediated signaling pathway |
| ubiquitin-ubiquitin ligase activity |
| filopodium tip |
| cellular response to interferon-beta |
| response to interferon-beta |
| positive regulation of peptidyl-threonine phosphorylation |
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| regulation of type I interferon-mediated signaling pathway |
| ubiquitin conjugating enzyme activity |
| regulation of peptidyl-threonine phosphorylation |
| positive regulation of cytokine-mediated signaling pathway |
| protein K48-linked ubiquitination |
| positive regulation of response to cytokine stimulus |
| protein polymerization |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| intrinsic apoptotic signaling pathway |
| regulation of ubiquitin-dependent protein catabolic process |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| regulation of proteasomal protein catabolic process |
| regulation of proteolysis involved in cellular protein catabolic process |
| ubiquitin-protein transferase activity |
| regulation of cellular protein catabolic process |
| response to endoplasmic reticulum stress |
| apoptotic signaling pathway |
| ubiquitin protein ligase binding |
| protein polyubiquitination |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| regulation of protein catabolic process |
| regulation of innate immune response |
| positive regulation of defense response |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| protein catabolic process |
| protein ubiquitination |
| regulation of proteolysis |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| regulation of cellular catabolic process |
| cellular protein-containing complex assembly |
| positive regulation of immune response |
| cellular homeostasis |
| cellular macromolecule catabolic process |
| apoptotic process |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| macromolecule catabolic process |
| programmed cell death |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| proteolysis |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.635 |
| GFPT1 | 0.581 |
| PLAA | 0.577 |
| BAP1 | 0.52 |
| MFN1 | 0.52 |
| DOHH | 0.519 |
| NXT1 | 0.516 |
| CASP9 | 0.513 |
| ENY2 | 0.51 |
| APAF1 | 0.504 |
| RPTOR | 0.502 |
| CTDNEP1 | 0.499 |
| HSPD1 | 0.495 |
| PPP2R3C | 0.493 |
| TRIAP1 | 0.481 |
| MEAF6 | 0.479 |
| PMM2 | 0.477 |
| HCCS | 0.476 |
| CSNK2B | 0.473 |
| ALG5 | 0.473 |
| UAP1 | 0.47 |
| THG1L | 0.467 |
| RNMT | 0.458 |
| GABPA | 0.455 |
| RTCB | 0.455 |
| RAD23B | 0.455 |
| UBQLN1 | 0.453 |
| DPAGT1 | 0.448 |
| NAE1 | 0.447 |
| DIABLO | 0.445 |
| NSMCE1 | 0.442 |
| CYCS | 0.442 |
| ALG1 | 0.441 |
| UBE2J1 | 0.441 |
| FAF2 | 0.436 |
| UBE2G2 | 0.432 |
| TMED10 | 0.432 |
| SLC25A26 | 0.432 |
| VMP1 | 0.43 |
| CRLS1 | 0.427 |
| FGFR1OP | 0.427 |
| NSD1 | 0.425 |
| GMPPB | 0.424 |
| GTF3A | 0.423 |
| TRMT5 | 0.419 |
| SUV420H1 | 0.418 |
| ATP5J | 0.417 |
| ID3 | 0.416 |
| PPA2 | 0.414 |
| DHPS | 0.413 |
| SRP72 | 0.411 |
| SRP14 | 0.404 |
| BAK1 | 0.4 |
| MTOR | 0.4 |
| RPE | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5908
- Expression level (log2 read counts): 6.82
Expression Distribution
UBE2K Expression in NALM6 Cells: 6.82
