WDR26

Gene Information

Official Symbol: WDR26
Official Name: WD repeat domain 26
Aliases and Previous Symbols: N/A
Entrez ID: 80232
UniProt: Q9H7D7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia- mediated autophagy and mitophagy (By similarity). {ECO:0000250|UniProtKB:F1LTR1, ECO:0000269|PubMed:15378603, ECO:0000269|PubMed:19446606, ECO:0000269|PubMed:23625927, ECO:0000269|PubMed:26895380, ECO:0000269|PubMed:27098453}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-4.58
Thimerosal 0.85μM R08 exp529	-3.63
Palbociclib 1μM R07 exp382	-3.35
3-Bromopyruvate 7μM R04 exp175	-3.09
FK-506 30μM R07 exp359	-3.01
UM0129480 7μM R02 exp85	-2.99
Mdivi-1 15μM R05 exp217	-2.93
BVD-523 15μM R02 exp67	-2.92
MK-1775 0.32μM R02 exp75	-2.84
UMK57 1μM R01 exp59	-2.74
Hydroxyurea 100μM R07 exp329	-2.63
BML-284 0.09μM R08 exp460	-2.48
WYE-354 6μM R02 exp90	-2.46
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.4
Cryptotanshinone 12μM R05 exp227	-2.4
Pterostilbene 16μM R02 exp78	-2.28
Dorsomorphin 5μM R07 exp357	-2.24
Fluvastatin 2.2μM R06 exp282	-2.2
Resveratrol 16μM R03 exp147	-2.2
Quercetin 20μM R08 exp517	-2.14
Vinblastine 0.002μM R01 exp60	-2.06
Dinaciclib 0.007μM R07 exp355	-1.96
Docetaxel 0.002μM R01 exp45	-1.95
Cerivastatin 0.15μM R05 exp226	-1.9
iCRT14 30μM R08 exp492	-1.89
Zebularine 20μM R07 exp423	-1.88
YM155 0.0002μM R01 exp61	-1.87
CoCl2 18μM R07 exp346	-1.85
Diepoxybutane 3μM R07 exp354	-1.85
IU1-C 25μM R04 exp183	-1.8
JQ1 0.8μM R08 exp435	-1.8
Demecolcine 0.03μM R05 exp228	-1.78
Bleomycin 5μM R08 exp459	-1.71
FK-506 5μM R07 exp358	-1.7
NN-Dimethylsphingosine 2.5μM R08 exp508	1.94
EPZ-5676 30μM R05 exp233	1.94
Pyridostatin 4μM R05 exp240	1.98
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.06
I-BRD9 4μM R07 exp365	2.07
LLY-284 2.6μM R06 exp291	2.2
Nicotine 3000μM R08 exp510	2.24
Azithromycin 100μM R08 exp452	2.25
AICAR 240μM R05 exp211	2.28
Arsenate 40μM R06 exp264	2.36
GSK626616 14μM R08 exp485	2.64
Rapamycin 1μM R00 exp29	3.08
AICAR 240μM R03 exp116	3.34
Rapamycin 2μM R07 exp306	3.88
Rapamycin 0.001μM R08 exp429	3.94
Rapamycin 10μM R00 exp30	4.43

Gene	Correlation
YPEL5	0.822
UBE2H	0.765
GID8	0.751
MAEA	0.697
MEMO1	0.526
RMND5A	0.506
CNOT8	0.473
OTUB1	0.466
GSKIP	0.449
ANP32A	0.446
HGC6.3	0.433
FKBP1A	0.422
CNOT2	0.416
PCGF1	0.415
KDM6A	0.413
GSK3B	0.41

Global Fraction of Cell Lines Where Essential: 30/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	4/26
breast	3/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	5/75
lymphocyte	0/16
ovary	3/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3796
Expression level (log2 read counts): 6.83

Expression Distribution

ubiquitin ligase complex
mitochondrion